Friday, November 30, 2012

Soccer Goalkeeping Tips ? Recreation and Sports

The goalkeeper?s job is definitely the toughest of all soccer players. Even though a defender, midfielder or attacker can get off with a few blunders once in a while, a goal keeper?s blunders really are a lot more noticeable. To complicate things even further, modern goalkeepers have a whole lot more attributions than before. They need to coordinate the defense. They quite often have to work as sweepers, and they are able to fire off lethal counter attacks immediately after a clean save.

1 Versus 1 is a very popular routine. That being said, it?s very effective given that goal keepers are bound to become caught in a one on one challenge against an opposing attacker in practically every single game. Add to that, at beginner or youth levels, in which defenses are less demanding than they are with the professionals, 1-on-1s are quite typical for goalkeepers. You need to train them properly.

Ab Volley is one of the toughest goal keeping drills. If executed correctly, it?s an extremely effective one. Here?s how it goes: your goalie must remain on his bottom, in the very same position he?d do ab situps in. You or a teammate will need to throw the ball towards him and while he?s doing ab situps, he will pass it back to you. To speed things up a little, you can have an additional group of 8-10 players behind the goal, returning the balls back to the firing squad.

Automatic Fire. Have 8-10 players stand at about twenty to thirty yards from the goal, each with his or her own ball. At your signal, the attackers must, 1 by 1, run forward and kick the ball from a distance you specified earlier. Your goal keeper must be under a constant rain of shots, jumping from one particular post to the other to save the ball. It is not really that essential if he saves them or not, it is crucial that he understands the way to react rapidly and get up from the floor fast and be prepared for an additional shot.

Visit www.lacrossegoals.org to learn more about the similarities of soccer and lacrosse.


Tags: football, goalie, goalkeeper, soccer

Source: http://recreationandsports.russiacourse.com/uncategorized/soccer-goalkeeping-tips/

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Chinese police plan to board vessels in disputed seas

BEIJING/MANILA (Reuters) - Police in the southern Chinese island province of Hainan will board and search ships which illegally enter what China considers its territory in the disputed South China Sea, state media said on Thursday, a move likely to add to tensions.

The South China Sea is Asia's biggest potential military trouble spot with several Asian countries claiming sovereignty over waters believed to be rich in oil and gas.

The shortest route between the Pacific and Indian Oceans, it has some of the world's busiest shipping lanes. More than half the globe's oil tanker traffic passes through it.

New rules, which come into effect on January 1, will allow Hainan police to board and seize control of foreign ships which "illegally enter" Chinese waters and order them to change course or stop sailing, the official China Daily reported.

"Activities such as entering the island province's waters without permission, damaging coastal defense facilities and engaging in publicity that threatens national security are illegal," the English-language newspaper said.

"If foreign ships or crew members violate regulations, Hainan police have the right to take over the ships or their communication systems, under the revised regulations," it added.

Hainan, which likes to style itself as China's answer to Hawaii or Bali with its resorts and beaches, is the province responsible for administering the country's extensive claims to the myriad islets and atolls in the South China Sea.

The Philippines, which also has claims to parts of the South China Sea, said the move could violate international maritime laws allowing the right of passage and accused Beijing of trying to escalate tension in the area.

"That cannot be. That's a violation of the international passage (rights)," Marine Lieutenant-General Juancho Sabban, commander of military forces in the western Philippines, which covers the contested area.

"That's too much. While we are exerting all peaceful means, that is what they are doing."

Raul Hernandez, a spokesman for the Philippines' Foreign Ministry, was more circumspect, saying the government was still checking the reports.

"If it is true, it will pose a concern to the Philippines and the international community," he added.

In Washington, U.S. military officials said the report mentions only police in Hainan province, not military forces, so the intended scope of the policy is not clear.

Hainan's policy was unlikely to affect the behavior of U.S. vessels operating in international waters, said the officials.

"As a Pacific power, we have a national interest in freedom of navigation, in unimpeded economic development and commerce, and the rule of law," Rear Admiral John Kirby, a Navy spokesman.

"Freedom of navigation is essential for any maritime nation. And it applies to all of them, everywhere," he said.

The United States is a security ally of the Philippines.

Rex Robles, a retired senior Philippine naval officer and security analyst, said China was just testing the reaction.

"Those warnings are not directed at us. They might be trying to find out how far the United States would react because this could affect freedom of navigation in one of the busiest sea lanes in the world. If this is an official policy announced by Beijing, this is very serious and a cause of concern."

U.S. China expert Bonnie Glaser said the Chinese "believe they are using different elements of Chinese power very effectively ... and they feel that anything that is not using force, that is under that bar, is acceptable - including economic coercion against the Philippines."

"They look at the U.S. and say 'the U.S. is not going to risk a confrontation with China over these issues.' In some ways, they are calling the U.S. bluff," said Glaser, a senior adviser at the Center for Strategic and International Studies.

China has said in the past it will respect freedom of navigation in the South China Sea and that it has no intention of trying to restrict access to the area's vital shipping lanes for legitimate vessels.

Chinese Foreign Ministry spokesman Hong Lei said his government, which says it will brook no outside interference in its sovereignty claims, was perfectly within its rights in allowing police to board vessels in the South China Sea.

"Management of the seas according to the law is a sovereign nation's legitimate right," he told a daily news briefing.

China's assertion of sovereignty over the stretch of water off its south coast and to the east of mainland Southeast Asia has set it directly against Vietnam and the Philippines, while Brunei, Taiwan and Malaysia also lay claim to parts.

China occasionally detains fishermen, mostly from Vietnam, whom it accuses of operating illegally in Chinese waters, though generally frees them quite quickly.

The China Daily said that the government will also send new maritime surveillance ships to join the fleet responsible for patrolling the South China Sea.

The stakes have risen in the area as the U.S. military shifts its attention and resources back to Asia, emboldening its long-time ally the Philippines and former foe Vietnam to take a tougher stance against Beijing.

China has further angered the Philippines and Vietnam by issuing new passports showing a map depicting China's claims to the disputed waters.

(Additional reporting by Michael Martina in BEIJING and David Alexander and Paul Eckert in WASHINGTON, Editing by Jonathan Thatcher and Sandra Maler)

Source: http://news.yahoo.com/chinese-police-plan-board-vessels-disputed-seas-001626842.html

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Robotic equivalent of a Swiss army knife: Reconfigurable robot a step toward something that can become almost anything

ScienceDaily (Nov. 30, 2012) ? The device doesn't look like much: a caterpillar-sized assembly of metal rings and strips resembling something you might find buried in a home-workshop drawer. But the technology behind it, and the long-range possibilities it represents, are quite remarkable.

The little device is called a milli-motein -- a name melding its millimeter-sized components and a motorized design inspired by proteins, which naturally fold themselves into incredibly complex shapes. This minuscule robot may be a harbinger of future devices that could fold themselves up into almost any shape imaginable.

The device was conceived by Neil Gershenfeld, head of MIT's Center for Bits and Atoms, visiting scientist Ara Knaian and graduate student Kenneth Cheung, and is described in a paper presented recently at the 2012 Intelligent Robots and Systems conference. Its key feature, Gershenfeld says: "It's effectively a one-dimensional robot that can be made in a continuous strip, without conventionally moving parts, and then folded into arbitrary shapes."

To build the world's smallest chain robot, the team had to invent an entirely new kind of motor: not only small and strong, but also able to hold its position firmly even with power switched off. The researchers met these needs with a new system called an electropermanent motor.

The motor is similar in principle to the giant electromagnets used in scrapyards to lift cars, in which a powerful permanent magnet (one that, like an ordinary bar magnet, requires no power) is paired with a weaker magnet (one whose magnetic field direction can be flipped by an electric current in a coil). The two magnets are designed so that their fields either add or cancel, depending on which way the switchable field points. Thus, the force of the powerful magnet can be turned off at will -- such as to release a suspended car -- without having to power an enormous electromagnet the whole time.

In this new miniature version, a series of permanent magnets paired with electromagnets are arranged in a circle; they drive a steel ring that's situated around them. The key innovation, Knaian explains, is that "they do not take power in either the on or the off state, but only use power in the changing state," using minimal energy overall.

The milli-motein concept follows up on a paper, published last year, which examined the theoretical possibility of assembling any desired 3-D shape simply by folding a long string of identical subunits. That paper, co-authored by Cheung, MIT professor Erik Demaine, alumnus Saul Griffith, and former Computer Science and Artificial Intelligence Laboratory research scientist Jonathan Bachrach, proved mathematically that it was possible for any 3-D shape to be reproduced by folding a sufficiently long string -- and that it's possible to figure out how to fold such a string, and the exact steps needed to successfully reach the desired endpoint.

"We showed that you could make such a universal system that's very simple," Cheung says. While he and his colleagues have not yet proved a way of always finding the optimal path to a given folded shape, they did find several useful strategies for arriving at practical folding sequences.

Demaine points out that the folding of the shape doesn't have to be sequential, moving along the string one joint at a time. "Ideally, you'd like to do it all at once," he says, with each of the joints folding themselves to the desired configuration simultaneously so that the loads are distributed.

Other researchers, including some at MIT, have explored the idea of fashioning reconfigurable robots from a batch of separate pieces that could self-assemble into different configurations -- an approach sometimes called "programmable pebbles." But Gershenfeld's team found that a string of subunits capable of folding itself into any shape could be simpler in terms of control, power and communications than using separate pieces that must find each other and assemble in the right order. "You can just pass signals down the chain," Knaian says.

It's part of an overall approach, Gershenfeld explains, to "turning data into things." In an article in the current issue of the magazine Foreign Affairs, he describes a technology roadmap for accomplishing that, and its policy implications. He and his colleagues have established a global network of more than 100 "fab labs" that provide community access to computer-controlled fabrication tools. Today, the design information is contained in an external computer rather than in the materials being manufactured, but the research goal is to digitize the materials themselves so that they can ultimately change their own shape, as the milli-motein does.

Hod Lipson, an associate professor of mechanical and aerospace engineering and computing and information science at Cornell University, says, "This result brings us closer to the idea of programmable matter -- where computer programs and materials merge to form a new kind of matter whose shape and function can be programmed -- not unlike biology. Many people are excited today to learn about 3-D printing and its ability to fabricate any shape; Gershenfeld's group is already thinking about the next episode, where we don't just control the shape of objects, but also their behavior."

The milli-motein is part of a family of such devices being explored at size scales ranging from protein-based "nanoassemblers" to a version where the chain is as big as a person, Gershenfeld says. Ultimately, a reconfigurable robot should be "small, cheap, durable and strong," Knaian says, adding that right now, "it's not possible to get all of those." Still, he points out, "Biology is the existence proof that it is possible."

The MIT researchers' work could lead to robotic systems that can be dynamically reconfigured to do many different jobs rather than repeating a fixed function, and that can be produced much more cheaply than conventional robotics.

The development of the milli-motein was supported by the U.S. Defense Advanced Research Projects Agency's Maximum Mobility and Manipulation and Programmable Matter projects.

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Story Source:

The above story is reprinted from materials provided by Massachusetts Institute of Technology. The original article was written by David L. Chandler.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Note: If no author is given, the source is cited instead.

Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_science/~3/IU_HhUYDock/121130132743.htm

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Prenatal intervention reduces learning deficit in mice

ScienceDaily (Nov. 29, 2012) ? Mice with a condition that serves as a laboratory model for Down syndrome perform better on memory and learning tasks as adults if they were treated before birth with neuroprotective peptides, according to researchers at the National Institutes of Health.

Down syndrome results when an individual receives an extra copy of chromosome 21. According to the Centers for Disease Control and Prevention, Down syndrome occurs in 1 of every 691 births. Features of Down syndrome include delays in mental and physical development and poor muscle tone. These features may vary greatly, ranging from mild to severe.

The researchers studied growth factors that are important at certain key stages of brain development in the womb. Named for the first three amino acids making up their chemical sequence, NAP and SAL, are small peptides (small protein sub units) of two proteins. These two proteins enhance the ability of brain cells to receive and transmit signals, and enable them to survive. (NAP is an abbreviation for NAPVSIPQ and SALfor SALLRSIPA.)

The mice in the study had an extra copy of mouse chromosome 16, which has mouse counterparts to 55 percent of the genes on human chromosome 21.The researchers treated pregnant mice with NAP and SAL for five days, then tested the mouse offspring at 8 to 12 months of age, comparing them to mice treated with a saline solution (placebo). Mice with the extra chromosomal material that were treated with NAP and SAL in the womb learned as well as mice that did not have the extra chromosome, and significantly faster than mice with the extra chromosome that were treated with saline solution.

"Our study has provided important information that may help in the understanding of Down syndrome," said senior author Catherine Y. Spong, M.D., chief of the unit on perinatal and developmental neurobiology at the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), the NIH institute where the research was conducted.

Dr. Spong collaborated with first author Maddalena Incerti, M.D., Kari Horowitz MD, Robin Roberson, Daniel Abebe, Laura Toso, M.D., and Madeline Caballero, all of the NICHD Unit on Perinatal and Developmental Neurobiology. Dr. Incerti also is affiliated with the University of Milano-Bicocca, Italy, and Dr. Horowitz now is affiliated with the University of Connecticut, Farmington.

Their findings appear online in PLOS ONE.

In an earlier study, Dr. Spong and her colleagues found that, if treated with NAP and SAL in the womb, mice with the extra copy of chromosome 16, achieved developmental milestones earlier than did mice with an extra copy of chromosome 16 that had not been treated. In that study, the researchers examined developmental milestones for sensory, motor skill, and muscle tone development in the first three weeks of life.

"In our earlier work, we showed that treating the mice during pregnancy could prevent developmental delay as assessed with milestones," Dr. Spong said. "In this study, we showed that treatment with NAP and SAL not only puts the animals on a typical developmental trajectory, it also improves their ability to learn.

For the current study, pregnant mice received injections of the two protein fragments starting eight days after conception. This is equivalent to the end of the first trimester in a human pregnancy.

The researchers tested the learning skills of the mice when the animals reached adulthood. The mice were placed in a tank of water on a clear platform. The tank had symbols on each wall that the mice could use to orient themselves. Researchers then placed the mice directly in the water and timed how long it took them to locate the platform. With repeated trials, the mice become more adept at the task and take less time to reach the platform.

Over five days of testing, the researchers found that the time spent searching for the platform decreased substantially for all groups except the mice with the extra copy of chromosome 16 that were not treated with NAP and SAL in the womb.

The research of Dr. Spong's team is part of an NIH-wide focus on Down syndrome outlined in a 2007 Down syndrome research plan. The plan highlights research priorities for the field, including establishing a Down syndrome patient registry, which was announced Oct. 25, 2012.

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The above story is reprinted from materials provided by NIH/National Institute of Child Health and Human Development.

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Journal Reference:

  1. Maddalena Incerti, Kari Horowitz, Robin Roberson, Daniel Abebe, Laura Toso, Madeline Caballero, Catherine Y. Spong. Prenatal Treatment Prevents Learning Deficit in Down Syndrome Model. PLoS ONE, 2012; 7 (11): e50724 DOI: 10.1371/journal.pone.0050724

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/h2KUJD8xa7o/121130095257.htm

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This Portable Bluetooth Speaker Is Different Because It Looks Weird and You Can't Break it

The world is seething with a billion cheap, portable Bluetooth speakers. To differentiate itself from the pack, Boom Movement has created this thing. It's called the Urchin, and the silicone cloaked beast looks as bizarre as its name implies. It's also certified shock and water-resistant. More »


Source: http://feeds.gawker.com/~r/gizmodo/full/~3/VeuExAu4t30/this-bluetooth-speaker-is-different-because-it-looks-weird-and-you-cant-break-it

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Military spouses to have easier time finding work, providing for family under legislation

U.S. military spouses who move to Michigan will have an easier time finding work under legislation introduced this week by Rep. Mike Shirkey that cuts red tape for the? licensing requirements of teachers, health-care workers and real estate agents.

House Bills 5994-96 wouldallow Michigan to recognize the validteaching certificates, and health care and real estate licenses issuedfrom other states in a more expedited fashion?for military spouses having to relocate to Michigan.? Temporary licenses can?be issued to fill the gap between application and final approval from the state.

"We owe a tremendous debt of gratitude to our military families, and government bureaucracy should never hinder a military spouse from finding work as quickly as possible," said Shirkey, R-Clarklake.? "Moving from state to state can be an unfortunate part of life for most military families, and we should do everything we can to warmly welcome them to Michigan."

More than 100,000 military spouses with professional licenses have trouble transferring their licenses as they move from state to state, according to the White House.? Military spouse unemployment is close to 26 percent, more than double the national average.

"As we celebrate Veterans Day this Monday, we should remember that we must help veterans and their families throughout the entire year," Shirkey said.? "Moving to a new statecan be a hectic and uneasy time, especially if a military spouse is without work.? We need to expedite these temporary licenses for these spouses to find work and help provide for their families."

There are currently about 20 states that have approved legislation to ease the burden of military spouse?s career portability due to military moves.?

?The bills now go to various committees for consideration.

Source: http://www.gophouse.com/readarticle.asp?ID=9336&District=65

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Mercer Island boys swimming | Winter sports previews

By MEGAN MANAGAN
Mercer Island Reporter Reporter
November 26, 2012 ? Updated 4:52 PM?

Coach: Chauntelle Johnson

Number of

athletes: Over 60

Last season: The Islanders finished second in state, ending a six-year state title run. Mercer Island won the KingCo meet and took second to Lakeside during the SeaKing District meet ? the team that would go on to beat Mercer Island in the state finals.

Strengths: ?Our sprint freestyles,? said coach Chauntelle Johnson. ?We did time trials last week and had a lot of guys under 24 seconds in the 50.?

?Diving,? said captain Sam Peterson. The team will have at least four seniors and one sophomore diving this season. ?And we have some great relays,? he added.

This season the team has a lot of younger swimmers, said Johnson.

?A lot of new guys who really want to get better,? she said.

?Everyone?s really supportive,? said captain Harrison Leeds.

Focus: ?Getting their endurance back,? said Johnson. ?Some of the guys play water polo, so working on their mechanics, and for others, even our year-round swimmers, getting them ready for a lot of racing.?

?Teamwork,? said senior Sam Chong. ?Showing them that when we work as a whole, we can do something great.?

?We want to make sure that everyone improves and has a KingCo time,? said Peterson.

Captains: Seniors Cody Hall, Sam Chong, Sam Peterson, Harrison Leeds

Meet to watch: Newport, Bellevue, Bainbridge Island, Kennedy Catholic, Lakeside

?We?re also going to the Kentridge Invitational,? said Johnson.

?Bellevue,? said the captains. ?It?ll be close, but we can do it,? said Leeds.

?Lakeridge, because they beat us last year at state; it?ll be tough,? said Chong.

Contact Mercer Island Reporter Reporter Megan Managan at mmanagan@mi-reporter.com or (206) 232-1215 ext. 5054.

Source: http://feeds.soundpublishing.com/~r/mirsports/~3/wKiuv8Ei4cY/180921491.html

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2012 a Big Year for Real-Estate Agent Activity, According to National ...

Homebuyers who used Realtors, including agents from Waterfront Properties and Club Communities, jumped 20 percent in a decade.

Jupiter, Fla. (PRWEB) November 29, 2012

The National Association of Realtors has tracked the traits of homebuyers and homesellers this year and, in a recent report of its findings, said married couples have captured the largest share of both markets.

The report found those in wedded bliss account for 76 percent of the homeselling market and 65 percent of the homebuying market, with the latter figure is at its highest level since 2001.

Realtors at Waterfront Properties and Club Communities said they have witnessed the market trend in South Florida markets, where many couples take their honeymoons. South Florida ? Palm Beach and Martin counties in particular ? offers desirable oceanfront homes for sale and a year-round calendar of great weather, cultural events and entertainment.

The town of Jupiter and the village of Juno Beach, which are filled with luxury condominiums, including Jupiter by the Sea and Ocean Royale, boast beautiful beaches with offshore reefs perfect for snorkeling, diving and fishing. Boating opportunities abound, including paddling, sailing and annual powerboat races. It?s no wonder newlyweds are buying homes here.

The association report also has statistics on first-timers. The percentage of buyers purchasing homes for the first time stands at 39 percent, while the percentage of first-time sellers is 34 percent.

Other statistics in the report focus on salaries and earnings. The average annual income of homesellers is $95,400. In the south, which includes Waterfront Properties? markets, the average annual income is $100,600.

As for homesellers, their average yearly earnings are $78,600 ($80,400 in the south).

The association also tracked the habits of buyers and sellers looking for a real-estate agent. Here?s what it concluded: Both buyers (40 percent) and sellers (38 percent) predominantly hired Realtors through referrals from their friends and relatives. Buyers hired agents based on their ability to negotiate prices and sales terms, while sellers looked for agents who could close the deal within a targeted timeframe and market their home to potential buyers.

In all, 89 percent of all homebuyers employed real-estate agents in 2012, compared with 69 percent in 2001.

Rob Thomson
Waterfront Properties Club Communities
561.746.7272
Email Information

Source: http://nationalrealtynews.com/national-association-of-realtors/2012-a-big-year-for-real-estate-agent-activity-according-to-national-association/

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'That 70s Show' star arrested in North Carolina

STATESVILLE, N.C. (AP) ? "That '70s Show" star Lisa Robin Kelly is free on bond after being arrested for assault.

Police in the Charlotte, N.C., suburb of Mooresville arrested the 42-year-old Kelly and 61-year-old husband Robert Joseph Gilliam after responding to a disturbance at their home Monday. Both are free on bond.

Gilliam is charged with misdemeanor assault on a female. Kelly is charged with misdemeanor assault. They were taken to the Iredell County Detention Center and released on $500 bond apiece. They have a court date of Jan. 25. It's not known if either has an attorney.

Kelly portrayed Laurie Forman, sister of Topher Grace's lead character Eric, on the FOX series, which ended in 2006. She also appeared on the TV shows "Murphy Brown" and "Married . . . With Children."

Source: http://news.yahoo.com/70s-show-star-arrested-north-carolina-040626459.html

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American Horror Story, Season 2

Lily Rabe as Sister Mary Eunice and Fredric Lehne as Frank in 'American Horror Story: Asylum.'

Lily Rabe as Sister Mary Eunice and Fredric Lehne as Frank in 'American Horror Story: Asylum.'

Photo by Michael Becker/FX.

Every week in?Slate?s?American Horror Story TV club, J. Bryan Lowder will have an IM conversation with a different?AHS fan. This week, he rehashes episode 2.7 with Abby Ohlheiser, a Slate contributor.

J. Bryan Lowder: Ok, Abby. I?m just going to say it. This evening may be remembered as the night American Horror Story jumped the shark. I don?t want to believe it?you know I?m a big fan of the overblown melodrama and camp sensibility of AHS?but there were a few moments in this episode where I paused the DVR and just shook my head. I mean, I was still kind of turned on by the hubris of having Frances Conroy as the Angel of Death, that fakeout where it looked like Sister Jude was going to be a freaking ghost for a minute, and poor, poor Lana being thrown from the frying pan into the fire and then basically into the core of the sun, but the more rational part of me just couldn?t deal with all of it at once.

Save me from myself?tell me that it worked for you, please!

Abby Ohlheiser: I'm sorry, Bryan, but I can't save you. I, too, am a fan of this show, but am finding myself mourning the death of the show's last feminist vestiges right now. Sister Jude's revelation that all she really wanted all along was a family elicited an audible sigh from me.

Lowder: Ew, yes, I had blocked that bit out. The most disappointing development in her storyline for me was that when she told the ANGEL OF DEATH to hold up for a minute, her "one last thing" that she needed to do was not burn down Briarcliff and fix all the injustices there, heroine style, but instead confess her hit-and-run to a family that probably didn't want to hear all that (and of course, we find out that their daughter hadn?t actually died). I realize we're on a soul-searching journey with Jude right now, but I'm about ready for her to get back in the real game.

Ohlheiser: Yes! ?unless that girl's dad gets to Jude first. Which, given the way this show is going, wouldn't surprise me.

Lowder: Not at all. But let's back up for a moment. I'm intrigued by your mention of the death of the show's feminist impulses. Was that comment pegged to a specific turn of events? I have to say, if I have to see Lana tortured or raped or just crying in another unimaginable situation one more time, I'm going to call sadism on the part of some writer. And thus far, such actions have been directed at...women.

Ohlheiser: Well, I should say that since our last (much more hopeful) conversation about the show's feminist streak, things have only gone downhill in that regard. So it's been a slow descent. But now that Frances Conroy's Angel of Death (as happy as I am to see her back in this show) has appeared to Jude, Grace [RIP], and Lana, I have a sinking feeling that the women in Briarcliff will only find liberation in death.

Lowder: That's a fascinating way of looking at it?that death is the only way out, especially for the women. I wonder if we're not heading to a Hamlet finish here, with basically everyone in the room dead except for our Horatio, who is, I guess, maybe Bloody Face? That would be a ballsy way to end a show, and somehow very Ryan Murphy. In any case, I'm totally at a loss for where we're going next, but it does seem like everyone who has escaped is getting pulled back to Briarcliff, which is now controlled by our possessed nun friend, Sister Mary Eunice. What did you think of that bitch-slap of a scene between her and Dr. Arden?

Ohlheiser: I mean, I kind of saw it coming. It made me wonder if the evil thing possessing her chose Sister Mary on purpose?she's pretty much Arden's biggest weakness. Or was. Whatever it is she's doing, he clearly is a big central part of it. Now against his will, perhaps, but I'm finding it hard to have much sympathy for him. Especially now that he's grown from the simple sadist doctor we used to know into a Nazi sadist doctor.

Lowder: I know, that Nazi appellation is never really a good look. For me, Sister Mary's power trip has a certain perverse appeal, especially because I've always been attracted to narratives with a villain who knows all your secrets. However, I'm starting to wonder if the number of characters on this show possessing omnipotent or puppeteer-like knowledge?which now includes a demon, presumably an alien, Dr. Threadson and an angel?have reached a critical mass. There are so many people who KNOW ALL, and too much of that feels too oppressive to the normal characters to me. Do you feel any of this, or is it just my weird hang-up?

Ohlheiser: I feel you, though my reaction to the scene itself was a bit "ho, hum." I so very much wanted to love Sister Mary's takedown of Arden, but the thrill is kind of gone since she became omnipotent. I was much more interested in whether the Angel of Death represents more of a threat or of a rival to her. If she's a threat, then it opens up the universe even more, in yet another direction. If she's a rival, then I'll have to beg the writers not to introduce another extended catfight subplot to this show.

Lowder: That's a great point?I?m definitely hoping for threat, but I think it's smart that's the angel is more green than Glinda. An overly strong "good" force would be out of place here; plus, we did hear the angel confess that she does not judge, but only responds to "songs" or "cries." What that bodes for Mary's plans I can't yet discern.

OK, before we go, I just want to take a moment to highlight our favorite lines from this episode. Despite its violent context, I have to say I did enjoy Thredson's delightfully twisted "I can either cut you or strangle you; I don't believe in guns." Did you have a favorite?

Ohlheiser: My favorite was the campy Sister Mary/Devil talking to each other in the same body exchange, where (presumably) Mary's sobbing plea for freedom is shot down by her own "Shut up you stupid sow!" Followed by a delightfully calm, "She likes it here."

Lowder: HA, yes, that was divine! Well, it?s been nice chatting with ?one like me, but fallen;? however, I have other souls to bring mercy to before the night is out. Just sing, Abby, if you need me!

Ohlheiser: Night, Bryan. Here's hoping AHS doesn't need a merciful being of its own next week to rescue it from itself.

Thursday: What other writers and Slate commenters thought about Episode 7.

Source: http://feeds.slate.com/click.phdo?i=b2b9cfa45178e6fffc541679bd9dc729

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Today on New Scientist: 28 November 2012

Out-of-proportion black hole is a rare cosmic fossil

A fairly small galaxy is host to a strangely enormous black hole, which could be a remnant of a quasar from the dawn of time

Flowing lithium atoms form accidental transistor

A transistor that controls the flow of atoms, rather than electrons, could be used as a model to probe the mysterious electrical property of superconductivity

Europe in 2050: a survivor's guide to climate change

A new report gives a clear picture of how global warming is affecting Europe - so how must countries adapt to survive?

Arctic permafrost is melting faster than predicted

A UN report and NASA research highlight greenhouse gases from melting permafrost, which they say could warm Earth's climate faster than we thought

Cassini spots superstorm at Saturn's north pole

The end of Saturn's 15-year winter reveals a huge hurricane-like vortex at the centre of the mysterious hexagon that tops the ringed planet

Infinity in the real world: Does space go on forever?

Watch an animation that tries to pin down the size of the universe, the largest thing that exists

Endangered primates caught in Congolese conflict

As the UN warns of a growing humanitarian crisis in the Democratic Republic of the Congo, the advance of the M23 rebels also puts the region's gorillas and chimps at risk

Hive minds: Honeybee intelligence creates a buzz

Bees do remarkable things with a brain the size of a pinhead, raising some intriguing questions about the nature of intelligence for David Robson

Humans head for moon's orbit - and beyond

A NASA mission might focus on the dark side, while a private mission may attempt something even more novel

Europe has right stuff to take NASA back to moon

ESA's redesigned cargo drone will give NASA's Orion spacecraft air, power and manoeuvrability on two new trips to the moon

DNA imaged with electron microscope for the first time

The famous twists of DNA's double helix have been seen with the aid of an electron microscope and a silicon bed of nails

Holiday gifts: Books to give by

CultureLab picks the best books to delight the scientifically curious this holiday season

How do you solve a problem like North Korea?

Forging scientific links may be one of the best ways to help bring rogue states back into the international fold

What truly exists? Structure as a route to the real

Some say we should accept that entities such as atomic particles really do exist. Others bitterly disagree. There is a way out, says Eric Scerri

Gas explosion in Springfield points to ageing pipes

Gas company officials attributed natural gas explosion on 23 November to human error, but the pipeline's corrosion made it susceptible to puncture

Source: http://feeds.newscientist.com/c/749/f/492992/s/260fa880/l/0L0Snewscientist0N0Cblogs0Cshortsharpscience0C20A120C110Ctoday0Eon0Enew0Escientist0E280Enove0Bhtml/story01.htm

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Just When Was It A Great Idea To Take Out A Cash Advance ...

instant payday loans online Get unsecured personal loans in Lexington-Fayette, KY by using instant $ 300 payday loans online low apr .

Are you in the fiscal bind? Are you thinking of a payday advance to help you get out of it? Then, there are several crucial concerns to remember very first. A payday advance is an excellent choice, but it?s not appropriate for everyone. Getting some time to comprehend the details concerning your bank loan will help you to make informed fiscal choices.

While searching for a payday financial institution, usually do not worry about your credit ranking. All of that payday loan companies are going to appear and authenticate your wages and the cabability to repay the borrowed funds out of your after that paycheck. Some on-line places usually do not even run credit checks, and as an alternative rely on job confirmation alone and offer $700 right away to anybody.

Only take out a payday advance, in case you have not one other options. Payday advance suppliers normally cost debtors extortionate rates, and administration charges. As a result, you ought to explore other types of obtaining fast cash before, turning to a payday advance. You can, for instance, acquire some money from friends, or family members.

Payday loans certainly are a costly way of getting dollars that you require. Consider seeking an move forward by your job chances are it will be much less high-priced, and it can be simpler than you imagine. Just seek advice from your man sources business office to obtain the info, you will end up very happy you did.

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Make sure that you browse the rules and relation to your payday advance carefully, in order to stay away from any unsuspected surprises down the road. You should comprehend the entire bank loan commitment before signing it and receive your loan. This can help you produce a better option with regards to which bank loan you ought to accept.

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Request relatives and buddies to assist you to with dollars before you apply for any payday advance. Regardless of whether they generally do not provide you with the entire quantity you require, you can get a payday advance for any lower quantity. That could help you save funds in interest, so you do not have to pay for the payday advance firm rear as much.

Some pay day loans are called headline financial loans. They demand anyone seeking the borrowed funds to make use of the headline for vehicle as, security for the bank loan. This is certainly only an alternative if, the vehicle includes a clear headline with no liens connected. The headline is held from the loan provider right up until, the borrowed funds is completely paid off.

Even though the point of a payday advance is to get dollars in a hurry, don?t hurry on your own with the paperwork. Assess the stipulations of the bank loan carefully. The charges for low-settlement of this type of bank loan can be remarkably serious. It?s vital that you fully grasp your fiscal responsibilities and sense comfortable that you could accomplish them before making a responsibility.

Try not to come to be reliant on pay day loans, as appealing as it can certainly get. They ought to be thought of as an urgent situation-only source of information and never an extension of the typical paycheck. Phrases can get difficult and charges run high make use of them smartly so when a signal that you just possibly have to get your fiscal house in order in the near future.

Ideally, you possess discovered somewhat about pay day loans that you just did not know. Go ahead and take info you possess discovered on this page, and place it to great use. Usually do not make any hasty choices because they financial loans can be quite high-priced. It can be your best choice, but it really could also be your most detrimental.

Source: http://www.dgstradinginc.com/just-when-was-it-a-great-idea-to-take-out-a-cash-advance/

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Federal Report Could Lead To Greater Cancer Risk at Dirty Bomb Sites

People living near the site of a radiological attack could face greater cancer risks then what the government would normally allow if officials follow the anticipated recommendations of an upcoming report commissioned by the U.S. Homeland Security Department.

The report will likely suggest that a radiation dose to the human body of between 100 and 2,000 millirems per year is the target officials should keep in mind when deciding how to clean up after a ?dirty bomb? or nuclear terror attack, according to S.Y. Chen, a senior environmental engineer at Argonne National Laboratory in Illinois.

Roughly 1 in 23 people would be expected to develop cancer from receiving a 2,000 millirem dose of radiation annually for 30 years, based on estimates from the International Commission on Radiological Protection, a private, nongovernmental organization whose work Chen cites as the basis for the recommendations. Approximately 1 in 466 people would be expected to develop cancer from an annual dose of 100 millirems over the same time period, according to calculations Global Security Newswire conducted using ICRP projections.

?It is just ethically indefensible,? Daniel Hirsch, a nuclear policy lecturer at the University of California-Santa Cruz, told GSN. ?Anyone proposing such a thing should go to jail.?

Normally, remediation of toxic U.S. properties is designed so 1 out of 10,000 people exposed to a site for 30 years would be expected to develop cancer in a worst-case scenario. One in 1 million people would be expected to develop cancer in the best possible situation.

Chen, chairman of the panel writing the new report, said he and his colleagues do not believe these guidelines ? established in the 1980s by the Environmental Protection Agency?s Superfund program ? must be followed after a terrorist attack.

The experience of the Japanese in the wake of last year?s earthquake- and tsunami-induced nuclear power plant meltdowns proves the need to consider economic factors in carrying out a massive cleanup, Chen told GSN in a recent interview. He argued the Superfund program was developed to deal with contamination that is more limited in scope and is not applicable to terrorist situations.

?Bring Superfund to Japan and see how it?s going to work. It will fail miserably,? Chen said. In the event of a dirty bomb or nuclear attack, ?it won?t just be a Superfund-like community where several acres are contaminated,? he said. ?Everywhere everybody will get disrupted big time. You have to worry about your jobs, you worry about business, you worry about your livelihood on a daily basis. So all of the sudden it?s no longer a contamination issue, it?s a bigger society issue that everyone has to cope with.?

Many Superfund sites are actually larger than what federal officials and other experts typically describe when they discuss how much land they would expect a dirty bomb to contaminate, however. Such a weapon would use conventional explosives to disperse radioactive material over a relatively small area.

While an existing DHS guide that the forthcoming report is meant to supplement describes the probable affected area as ranging between ?a single building or city block? to ?conceivably several square miles,? Superfund sites often cover hundreds of square miles.

A major concern among watchdog groups is that the DHS guide, combined with the forthcoming report, will establish a precedent that will relax remediation standards not only for areas contaminated by dirty bombs, but also for the more routine cleanup of nuclear weapons facilities owned by the Energy Department and other sites with radioactive contamination.

In 2008, the Environmental Protection Agency drafted a similar guide that would have abandoned the Superfund approach to cleanup after a wide range of radiological incidents, including accidents at nuclear power plants and industrial facilities that use radioactive material. The Obama administration delayed action on the Bush-era draft; a revised version is now pending review at the White House Management and Budget Office.

Documents the agency released under the Freedom of Information Act show some EPA staff and state government officials objected to the proposed abandonment of Superfund guidelines.

Carl Spreng, a project manager at the Colorado Public Health and the Environment Department, told GSN the dose range Chen suggests as an alternative is ?way outside? what state officials ?would consider safe and have argued for many years.?

Read the full story here.

?

Source: http://news.yahoo.com/federal-report-could-lead-greater-cancer-risk-dirty-060003459--politics.html

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Thursday, November 29, 2012

Apple to start selling new, pricier iMacs Friday

Apple today announced that it will start selling its redesigned iMac desktop computers Friday, barely making a self-set deadline to ship some by the end of the month.

Apple's newest iMac will be available Nov 30.

The smaller 21.5-in. iMac -- Apple's most popular desktop -- will be available at the company's online and retail stores, as well as select authorized resellers, on Friday at prices starting at $1,299. Previously, Apple had promised to deliver that model in November.

The larger 27-in. iMac, which starts at $1,799, will be available for pre-order Friday, but won't ship until next month, Apple said.

To learn more and to read the entire article at its source, please refer to the following page, Apple to start selling new, pricier iMacs Friday- Computerworld - New Zealand

? ? ? ??

Article Tags

Source: http://feeds.dabcc.com/~r/presentation-virtualization/~3/s0wDycVNAQE/article.aspx

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Marissa Jaret Winokur?s Blog: Why Hurricane Sandy Hit Home for Me

"I know there are storms and disasters all the time, but this one really hit home to me. Now that I'm a parent, it all seems so incredibly sad and hard," the actress writes.

Source: http://feeds.celebritybabies.com/~r/celebrity-babies/~3/FFamH5_MSsM/

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Real Estate Weekly ? Blog Archive ? Manhattan mega-rentals: Why ...

214 Lafayette Street, listed at $100,000 a month

By Sarah Trefethen

Homeownership may be an American ideal, but not everyone with the means to buy a property chooses to do so.
And far from being limited to budget-conscious offerings, Manhattan?s rental listings include some truly jaw-dropping properties.

From 80 Washington Place in Greenwich Village (listed with Douglas Elliman for $95,000 per month) to 247 Central Park West on the Upper West Side (Sotheby?s International, $90,000 per month,) super-high end rentals can be found throughout Manhattan.

Factors that lead people to eschew a purchase in favor of a high-end rental are as varied as the individuals involved, but there are some common themes, brokers say. Among them are convenience, flexibility and, in some cases, the opportunity to live in a space that simply isn?t available for sale.

?Many people just prefer renting,? said Gary Malin, president of Citi Habitats. ?They have investments tied up in other assets they don?t want to liquidate.?

At the Waldorf Towers, located within the Waldorf-Astoria hotel, Margaret Bay of Brown Harris Stevens handles rentals with lease terms of one month or longer.

Among the listings currently available in the towers is a 6,000 s/f, five-bedroom apartment that was home to the composer Cole Porter from 1934 to 1964. The apartment ? like all the residences in the building ? comes with hotel amenities, including maid and room service, and is listed for $150,000 per month.

Other listings available at the East 50th Street address include two three-bedroom apartments, one for $135,000 and the other for a mere $95,000 per month.

Some tenants stay only a few months, Bay said, while others stay for decades. Rentals are popular with families whose homes are going through renovations, and people who are only planning to stay in New York for a few years.

One 10-year tenant moved in after a divorce because she simply didn?t want to go through the process of disclosing her finances to a co-op board, Bay said, while the towers are also popular with corporate tenants and diplomatic missions.

?We?re very accommodating,? she said. ?We can really make anything happen. If you need 20 bedrooms in six apartments we can do that.?

The apartments are usually rented furnished, Bay said, but with the right lease terms tenants can arrange to redecorate and even renovate to suit.

At 214 Lafayette Street in SoHo, on the other hand, the furnishings are part of the deal.

?We would consider it for the right number, but really it is furnished to perfection. The vibe of the furnishings perfectly match the space,? said Steve Halpern of Citi Habitats, who leases the 13,000 s/f, three-bedroom townhouse. ?I don?t think you?re going to love the house and not love the furniture.?

The owners, horror movie director Marcus Nispel and his songwriter wife Dyan, spent over ten years renovating the former power station that Halpern describes as ?an architectural masterpiece.?

The stonework in the bathrooms came from an old monastery in the south of France and the indoor swimming pool was featured in the music video for singer Beyonce?s video ?Halo.?

The appeal for tenants is ?not just the luxury the apartment allows, but it?s also in just how unique it is to live there,? Halpern said. The space is available at a day rate for parties and photo and video shoots, but it was rented for three months over the summer and Halpern said he?s shown it to a number of parties interested in one-year leases.

In addition to a prime location and unique setting, the meticulously finished home offers turn-key convenience.

?On the very high end of the rental side, people are not looking to rent apartments that need work,? Malin said.

Renting also saves residents the uncertainty of having to sell later in what might turn out to be a down real estate market.

?A lot of people like to rent the dream as opposed to buying the dream,? Malin said.

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Source: http://www.rew-online.com/2012/11/28/manhattan-mega-rentals-why-buy-when-you-can-rent-a-new-york-super-home-for-150000-a-month/

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Windows Server 2012 A Disruptive Force for Good

Windows Server 2012 will bring basic storage virtualization to the masses, writes Wikibon Analyst Scott Lowe in his latest Wikibon Professional Alert,?and while it doesn?t have the features of technology leader Nexenta,?it will benefit users and speed up the virtualization of large numbers of data centers.

Overall, he says, Windows Server 2012 is impressive in its data management tools. The virtualization comes in the form of Storage Spaces that allows users to pool multiple physical hard disk units to create highly resilient, reliable, feature-rich storage arrays for individual workloads. It includes centralized management, storage aggregation, elastic capacity expansion, and ?even thin provisioning.? And it comes as part of a familiar, standard product from a major vendor that has strong relationships with large numbers of organizations rather than as an exotic piece of extra software from a small startup. This means that every user that updates to Server 2012, something Lowe recommends companies do as quickly as possible because of the advantages it provides, will automatically have server virtualization capabilities running in-house.

However, this is only part of what Server 2012 offers. It also has deduplication built in, making this enterprise-level tool available to midrange companies to help control growing demand for disk space. And it has made ?massive improvements to the Server Message Block (SMB) protocol.? These have a major positive impact on the performance and reliability of storage-related network communications. The result is that administrators can continue to use their familiar structures while SQL databases, Exchange, and Hyper-V virtual machines can be stored on normal SBM 3-enhanced file shares. This eliminates the need to retrain staff to manage complex storage and configure iSCSI and Fiber Channel connections.

Scott?s recommendation: ?CIOs shoud take a critical look at Windows Server 2012 for what it brings to the table.? Certainly, he says, virtualizing storage has its risks, but it can also save a chunk, particularly for companies that are seeing storage costs decimating IT budgets. And, ?don?t forget that server virtualization used to be considered high risk, too.?

?

Like all Wikibon research, this Professional Alert is available without charge on the Wikibon?Web site. IT professionals are invited to register for free membership in the Wikibon community, which allows them to post comments on and make corrections to research and post their own questions, tips, Professional Alerts, and white papers. It also allows them to participate in the frequent Wikibon Peer Incite meetings and receive the Peer Incite newsletter.

Source: http://servicesangle.com/blog/2012/11/28/windows-server-2012-a-disruptive-force-for-good/

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Latino Action Network Blog: Congressional Hispanic Caucus Spells ...


The Congressional Hispanic Caucus announced today their principles on immigration reform. ?The CHC issued a document titled: "ONE NATION: Principles on Immigration Reform and Our Commitment to the American Dream" that spells out nine (9) principles for immigration reform including a path to permanent residency and eventual citizenship for the estimated 11 million undocumented immigrants in the United States. ?It also includes protections for same-sex couples. ? A copy of the document appears below.

Congressional Hispanic Caucus

The Honorable Charles Gonzalez, Chair

November 28, 2012

ONE NATION:

Principles on Immigration Reform and Our Commitment to the American Dream

Today, we declare our commitment to the American people to work tirelessly toward common-sense, comprehensive immigration reform that serves America?s interests, promotes fairness and the rule of law and contributes effectively and meaningfully to our economic well-being and recovery.

America has always been a nation of immigrants. In order to preserve our history, national identity and culture we must create a modern, 21st century legal immigration system that reflects our legacy. Therefore, we commit to fighting for principled, comprehensive immigration reform that:

1. Requires the estimated 11 million undocumented immigrants in the U.S. to register with the federal government, submit to fingerprinting and a criminal background check, learn English and American civics, and pay taxes to contribute fully and legally to our economy and earn a path to permanent residency and eventual citizenship;

2. Protects the unity and sanctity of the family, including the families of bi-national, same-sex couples, by reducing the family backlogs and keeping spouses, parents, and children together;

3. Attracts the best and the brightest investors, innovators, and skilled professionals, including those in science, technology, engineering, and math (STEM) studies, to help strengthen our economy, create jobs, and build a brighter future for all Americans;

4. Builds on the extraordinary success of the Deferred Action for Childhood Arrivals (DACA) program and incorporates DREAMers?those who were brought to the U.S. at a young age and are Americans but for a piece of paper?into the mainstream of life in the United States through a path to citizenship so that America benefits from their scholastic achievements, military service and pursuit of their dreams;

5. Includes a balanced, workable solution for the agriculture industry that ensures agricultural workers have a route to citizenship and employers have the workers and American agriculture continues to lead in our global economy;

6. Ends the exploitation of U.S. and immigrant workers by providing sufficient, safe, and legal avenues for foreign workers to fill legitimate gaps in our workforce, with full labor rights, protection from discrimination, and a reasonable path to permanency that lifts up wages and working conditions for both native and foreign-born workers and their families;

7. Ensures smart and reasonable enforcement that protects our borders and fosters commerce by targeting serious criminals and real threats at our northern and southern borders and promotes the safe and legitimate movement of people and goods at our ports of entry and which are essential to our economy;

8. Establishes a workable employment verification system that prevents unlawful employment and rewards employers and employees who play by the rules, while protecting Americans? right to work and their privacy; and

9. Renews our commitment to citizenship, to ensure all workers pay their fair share of taxes, fully integrate into our way of life and bear the same responsibilities as all Americans and reaffirms our shared belief that the Citizenship Clause of the Constitution is a fundamental freedom that must be preserved.

Our immigration laws ought to reflect both our interests and our values as Americans and we believe these principles are consistent with our nation?s commitment to fairness and equality. We commit to adhering to the above principles as we negotiate on behalf of all Americans in good faith with both parties and all stakeholders in the immigration reform debate. We acknowledge that the time to reform the system is long past due. We ask all sides to set aside the vitriol and gamesmanship that is often a part of this debate and that blocks our ability to truly solve the problem. The American people deserve nothing less.

[A copy of this document can be found on Congressman Gutierrez' website at:
http://gutierrez.house.gov/sites/gutierrez.house.gov/files/One%20Nation_Principles%20on%20Immigration%20Reform.pdf]

Source: http://latinoaction.blogspot.com/2012/11/congressional-hispanic-caucus-spells.html

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Chemists invent powerful toolkit, accelerating creation of potential new drugs

ScienceDaily (Nov. 28, 2012) ? Scientists at The Scripps Research Institute (TSRI) have invented a set of chemical tools that is radically simplifying the creation of potential new drug compounds.

Pharmaceutical chemists frequently seek to generate dozens or even hundreds of variations of a given compound to see which works best. The new toolkit -- described in the Nov. 28, 2012 issue of the journal Nature -- makes this process easier and cheaper, enabling previously time- and cost-prohibitive chemical modifications. This fundamental innovation is already being adopted by drug companies and is expected to speed the development of new compounds in other industries as well.

"Feedback from companies that have started to use this toolkit indicates that it solves a real problem for them by boosting their chemists' productivity and by expanding the realm of compounds that they can feasibly generate," said Phil S. Baran, PhD, a professor in the Department of Chemistry and a member of the Skaggs Institute for Chemical Biology at TSRI who led the work.

Robert Lees, PhD, of the National Institutes of Health's National Institute of General Medical Sciences, which partially funded the work, added, "Methods to predictably, selectively and efficiently functionalize a given C-H site are difficult to invent but highly significant for developing new therapeutic and diagnostic agents, and studying biomolecules. Practical chemistry for introducing fluorine atoms into organic compounds is also an important current need in medicinal chemistry. The new reagents developed by Professor Baran address both goals, and they will likely be widely utilized in both academic and industrial laboratories."

A Common and Useful Structure

The toolkit is a set of newly invented chemicals and methods for attaching functional groups of molecules to a series of common chemical structures known as nitrogen-containing heterocycles -- flat molecules with rings made of carbon atoms and at least one nitrogen atom. Though their name might seem esoteric, these structures are common in both natural and synthetic chemicals, and they are found in most drugs that are taken in pill form.

"Ironically, the properties that make nitrogen-containing structures so useful in medicines are what also make them so hard to modify," said Baran. The resistance of nitrogen heterocycles to modification by traditional techniques has slowed drug discovery and has put many potential modifications out of reach.

But Baran envisioned a different scenario. "The ideal for discovery chemists would be a method that works in water, in an open flask, with procedures that are simple enough to be automated," he said.

A few years ago Baran began to glimpse the possibility of achieving such a method. His lab had just succeeded in synthesizing a complex natural nitrogen heterocycle, palau'amine, a toxin made by sea sponges in the Western Pacific that has shown anticancer, antibacterial and antifungal pharmaceutical promise. "As we developed an understanding of how that compound reacts, we recognized that it might help us solve this larger problem that discovery chemists face," he said.

The nitrogen atoms in heterocycles are what make them so tricky to handle. Traditional methods of modification typically aim to block their influence before the addition of any modifying molecules, but this approach can be cumbersome and expensive. The experience with palau'amine, which features an extremely challenging nine nitrogen atoms per molecule, led Baran and his team to try to find chemical reagents -- tools, in effect -- that would modify heterocycles directly.

A More Direct Route

Direct methods already had existed, but they often require extreme temperatures as well as expensive and hazardous reagents. During 2010 and 2011, Baran's lab experimented with several comparatively safe chemical reagents that can work in mild conditions to make commonly desired heterocycle modifications, such as the addition of a difluoromethyl group. One of these new reagents, a zinc dialkylsulfinate salt (DFMS) designed to transfer the difluoromethyl group, turned out to work particularly well. "We quickly realized that we might be able to make related zinc sulfinate salts that would attach other functional groups to heterocycles," Baran said.

In the new report in Nature, Baran and his colleagues describe an initial toolkit consisting of ten of these zinc-based salts, each of which attaches a different functional group to a heterocycle framework. "We selected these groups because they are commonly used by medicinal chemists," said Fionn O'Hara, PhD, a postdoctoral researcher in the Baran laboratory who was a first author of the new report with postdoctoral researcher Yuta Fujiwara, PhD, and technician Janice A. Dixon.

"In many cases, chemists will be able to use these reagents sequentially to make more than one modification to a starting compound," noted Fujiwara. The groups that can be attached with the new reagents include trifluoromethyl, difluoromethyl, trifluoroethyl, monofluoromethyl, isopropyl and triethylene glycol monomethyl ether.

To demonstrate the ability of the reagents to work in biological media, Baran's team used them to difluoromethylate or trifluoromethylate heterocycles in a solution of cell lysate -- the contents of cells -- as well as to serve as a buffer medium, Tris, commonly used in lab-dish tests. To underscore the general robustness of the reagents, the team even carried out such modifications in a paper cup containing Oolong tea.

Baran's laboratory collaborated in the research with scientists from the pharmaceutical company Pfizer Inc. "They provided insight into the types of compounds that would be valuable, assistance with optimization, and, most importantly, testing of the chemistry in their drug discovery laboratories, where it is meant to be used," Baran said.

The first of the zinc sulfinate salts, DFMS, now also known as Baran difluoromethylation reagent, is already being manufactured in bulk and marketed by chemical suppliers, including Sigma-Aldrich Corporation. "There has been a lot of demand for that product from the first day we listed it, which is very rare," said Troy Ryba, manager of academic chemistry strategy at the firm Sigma-Aldrich.

Baran currently is working to expand his lab's initial toolkit to provide more heterocycle-modifying choices to chemists in the pharmaceutical industry and beyond. "We have a whole slew of new reagents in the pipeline," he said.

In addition to Baran, O'Hara, Fujiwara and Dixon, authors of the paper, "Practical, innate C-H functionalization of heterocycles" are Neal Sach and Michael R. Collins of Pfizer; and Erik Daa Funder, Darryl D. Dixon, Rodrigo A. Rodriguez, Ryan D. Baxter, Bart Herle and Yoshihiro Ishihara, of the TSRI Department of Chemistry.

Funding for the research was provided in part by a National Institute of General Medical Sciences grant (GM-073949) and by Pfizer Inc.

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Story Source:

The above story is reprinted from materials provided by Scripps Research Institute.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Yuta Fujiwara, Janice A. Dixon, Fionn O?Hara, Erik Daa Funder, Darryl D. Dixon, Rodrigo A. Rodriguez, Ryan D. Baxter, Bart Herl?, Neal Sach, Michael R. Collins, Yoshihiro Ishihara, Phil S. Baran. Practical and innate carbon?hydrogen functionalization of heterocycles. Nature, 2012; DOI: 10.1038/nature11680

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/R8tFOWIBIm0/121128132255.htm

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MSI announces Military Class II-certified AMD Llano mainboard with DirectX 11 graphics support!

Sorry, Readability was unable to parse this page for content.

Source: http://1887047.sites.myregisteredsite.com/index.php?news_no=955&func=newsdesc

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U.K.?s First 4G Network, EE, Increases Data Limits By ~60% On Some Mobile Broadband Price-Plans; Still No Unlimited Data Tariffs

Screen Shot 2012-11-28 at 12.15.56The U.K.'s first -- and currently only -- 4G network, run by carrier EE, has announced it is increasing the size of the data caps on some of its mobile broadband tariffs by around 60 percent, while keeping its pricing structure the same. The network has faced criticism for offering relatively small monthly data caps for a high-speed network.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/9ZGQXxMJZX4/

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Federal agencies have avoided $47 billion in improper payments ...

Wednesday, November 28th, 2012

Federal government agencies have avoided $47 billion in improper payments over the past three years, according to Danny Werfel, Controller of the Office of Management and Budget (OMB).? Werfel announced these results in a blog on the OMB website this week.

Even though the government will come up a bit short of its goal of $50 billion in improper payments avoidance by the end of FY2012, Werfel said the current results are significant and reflect an aggressive approach by agencies to eliminate wasteful improper payments.? As a result, he said the government-wide error rate has been reduced to 4.3 percent from 5.4 percent in FY2009.

Werfel pointed out that factoring in Department of Defense (DoD) commercial payments adds another $70 billion to avoided improper payments and lowers the government-wide error rate to 3.7 percent.

He also emphasized that federal agencies have recaptured $4.4 billion in overpayments since FY2009, more than twice the $2 billion goal.? Much of this success, he said, is due to the Medicare Fee-for-Service Recovery Audit Contractor program.

Werfel said agencies have been able to significantly reduce the level of improper payments by intensifying and expanding efforts to identify, recovering improper payments and establishing ?Do-Not-Pay? lists, and implementing provisions of the ?Improper Payments Elimination and Recovery Act?.? He said agencies have, for the first time, ?deployed cutting-edge forensic technologies? to curb improper payments.

Source: http://www.asmconline.org/2012/11/federal-agencies-have-avoided-47-billion-in-improper-payments/

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HN: Senator Okamura is Facebook age populist

?TK |

23 November 2012

Prague, Nov 22 (CTK) - Tomio Okamura, fresh senator and candidate for Czech president, is a populist of the new Facebook age, willing to fall as deep as needed and still seemingly be a successful businessman who can understand ordinary people, Jindrich Sidlo writes in Hospodarske noviny (HN) daily Thursday.

Okamura, a 40-year-old tourism businessman, joined the presidential contest after being elected an unaffiliated senator in October.

It has been clear for a long time that somebody like Okamura will appear on the Czech political scene, Sidlo says.

Far-right populist leader Miroslav Sladek and his Republican Party disappeared from politics nearly 15 years ago and his successors from the Workers' Party did not even succeed in becoming members of the regional council in the radical northern Bohemia with their primitive aggressive rhetorics, he adds.

"The attractive position is still vacant," Sidlo points out.

Okamura may even seriously influence the direct presidential election - either its outcome when he may win over voters of leftist candidates Milos Zeman (Party of Citizens' Rights, SPOZ) and Jiri Dienstbier (Social Democrats, CSSD), or by filing a complaint if it turns out that the more than 50,000 signatures supporting his candidacy were not only gathered very quickly but also in special magical ways, Sidlo writes.

In connection with a text praising the idea of communism that Okamura posted on his blog on Tuesday, Sidlo says Okamura may have problems with spelling, keeping to the point and being consistent in his opinions, yet he has perfectly mastered one fundamental part of politics - marketing.

Okamura is happy when somebody starts arguing with him, for example CSSD leader Bohuslav Sobotka, but there is no sense in trying to argue because it is like arguing with an eight-year-old kid, Sidlo writes.

Okamura is very grateful if people curse him because this only helps him on his way to become the king of the Czech political populism, Sidlo indicates.

This time Okamura wrote about communism, next time he will write about something else, whatever it may be, for example about Romanies who should be moved to their own state, Sidlo says, referring to previous controversial statements by Okamura.

If anybody labels Okamura a racist in relation to his views on Romanies, he will object that he himself is of Japanese origin, Sidlo writes.

"Political populists freely moving from the right to the left extreme bear no responsibility for their words: they talk nonsense and wait who gets caught," Sidlo says.

He adds that the populist business is based on permanently raising attention, which Okamura seems to be good at.

Jana Bobosikova must be jealous of him, Sidlo writes, referring to another presidential candidate and chairwoman of Sovereignty, a small populist party.

He says defence against Okamurism is not easy and there actually seems to be no effective defence against it.

It is clear, however, that Okamura himself has been in full control of his career so far, Sidlo notes.

It is Okamura who chooses the topics and he decides due to which he may be ridiculed. If people believe that they may unmask Okamura in a battle where Okamura himself chooses the weapons, they are mistaken, Sidlo writes.

Copyright 2011 by the Czech News Agency (?TK). All rights reserved.
Copying, dissemination or other publication of this article or parts thereof without the prior written consent of ?TK is expressly forbidden. The Prague Daily Monitor and Monitor CE are not responsible for its content.

Source: http://praguemonitor.com/2012/11/23/hn-senator-okamura-facebook-age-populist

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