sapiens siana: June 2012

Friday, June 8, 2012

Dad still "first choice", but Rand Paul backs Romney (reuters)

Share With Friends:

| Politics - Top Stories News, News Feeds and News via Feedzilla.

draft tracker the pirates band of misfits cleveland browns minnesota twins green bay packers bobby abreu 2012 draft

F-16 stops small plane in Obama's LA air space

[ [ [['Connery is an experienced stuntman', 2]], 'http://yhoo.it/KeQd0p', '[Slideshow: See photos taken on the way down]', ' ', '630', ' ', ' ', ], [ [['Connery is an experienced stuntman', 7]], ' http://yhoo.it/KpUoHO', '[Slideshow: Death-defying daredevils]', ' ', '630', ' ', ' ', ], [ [['know that we have confidence in', 3]], 'http://yhoo.it/LqYjAX ', '[Related: The Secret Service guide to Cartagena]', ' ', '630', ' ', ' ', ], [ [['We picked up this other dog and', 5]], 'http://yhoo.it/JUSxvi', '[Related: 8 common dog fears, how to calm them]', ' ', '630', ' ', ' ', ], [ [['accused of running a fake hepatitis B', 5]], 'http://bit.ly/JnoJYN', '[Related: Did WH share raid details with filmmakers?]', ' ', '630', ' ', ' ', ], [ [['accused of running a fake hepatitis B', 3]], 'http://bit.ly/KoKiqJ', '[Factbox: AQAP, al-Qaeda in Yemen]', ' ', '630', ' ', ' ', ], [ [['have my contacts on or glasses', 3]], 'http://abcn.ws/KTE5AZ', '[Related: Should the murder charge be dropped?]', ' ', '630', ' ', ' ', ], [ [['have made this nation great as Sarah Palin', 5]], 'http://yhoo.it/JD7nlD', '[Related: Bristol Palin reality show debuts June 19]', ' ', '630', ' ', ' ', ], [ [['have made this nation great as Sarah Palin', 1]], 'http://bit.ly/JRPFRO', '[Related: McCain adviser who vetted Palin weighs in on VP race]', ' ', '630', ' ', ' ', ], [ [['A JetBlue flight from New York to Las Vegas', 3]], 'http://yhoo.it/GV9zpj', '[Related: View photos of the JetBlue plane in Amarillo]', ' ', '630', ' ', ' ', ], [ [['the 28-year-old neighborhood watchman who shot and killed', 15]], 'http://news.yahoo.com/photos/white-house-stays-out-of-teen-s-killing-slideshow/', 'Click image to see more photos', 'http://l.yimg.com/cv/ip/ap/default/120411/martinzimmermen.jpg', '630', ' ', 'AP', ], [ [['Titanic', 7]], 'http://news.yahoo.com/titanic-anniversary/', ' ', 'http://l.yimg.com/a/p/us/news/editorial/b/4e/b4e5ad9f00b5dfeeec2226d53e173569.jpeg', '550', ' ', ' ', ], [ [['He was in shock and still strapped to his seat', 6]], 'http://news.yahoo.com/photos/navy-jet-crashes-in-virginia-slideshow/', 'Click image to see more photos', 'http://l.yimg.com/cv/ip/ap/default/120406/jet_ap.jpg', '630', ' ', 'AP', ], [ [['xxxxxxxxxxxx', 11]], 'http://news.yahoo.com/photos/russian-grannies-win-bid-to-sing-at-eurovision-1331223625-slideshow/', 'Click image to see more photos', 'http://l.yimg.com/a/p/us/news/editorial/1/56/156d92f2760dcd3e75bcd649a8b85fcf.jpeg', '500', ' ', 'AP', ] ]

[ [ [['did not go as far his colleague', 8]], '29438204', '0' ], [ [[' the 28-year-old neighborhood watchman who shot and killed', 4]], '28924649', '0' ], [ [['because I know God protects me', 14], ['Brian Snow was at a nearby credit union', 5]], '28811216', '0' ], [ [['The state news agency RIA-Novosti quoted Rosaviatsiya', 6]], '28805461', '0' ], [ [['measure all but certain to fail in the face of bipartisan', 4]], '28771014', '0' ], [ [['matter what you do in this case', 5]], '28759848', '0' ], [ [['presume laws are constitutional', 7]], '28747556', '0' ], [ [['has destroyed 15 to 25 houses', 7]], '28744868', '0' ], [ [['short answer is yes', 7]], '28746030', '0' ], [ [['opportunity to tell the real story', 7]], '28731764', '0' ], [ [['entirely respectable way to put off the searing constitutional controversy', 7]], '28723797', '0' ], [ [['point of my campaign is that big ideas matter', 9]], '28712293', '0' ], [ [['As the standoff dragged into a second day', 7]], '28687424', '0' ], [ [['French police stepped up the search', 17]], '28667224', '0' ], [ [['Seeking to elevate his candidacy back to a general', 8]], '28660934', '0' ], [ [['The tragic story of Trayvon Martin', 4]], '28647343', '0' ], [ [['Karzai will get a chance soon to express', 8]], '28630306', '0' ], [ [['powerful storms stretching', 8]], '28493546', '0' ], [ [['basic norm that death is private', 6]], '28413590', '0' ], [ [['songwriter also saw a surge in sales for her debut album', 6]], '28413590', '1', 'Watch music videos from Whitney Houston ', 'on Yahoo! Music', 'http://music.yahoo.com' ], [ [['keyword', 99999999999999999999999]], 'videoID', '1', 'overwrite-pre-description', 'overwrite-link-string', 'overwrite-link-url' ] ]

boston marathon tu pac hologram shuttle pippa middleton space shuttle discovery kevin youkilis spacex

Thursday, June 7, 2012

White House: ?No? to independent probe of leaks

bcs jay z glory alabama crimson tide barry larkin jay z new song torrie wilson alabama lsu

Stress may delay brain development in early years

ScienceDaily (June 6, 2012) ? Stress may affect brain development in children -- altering growth of a specific piece of the brain and abilities associated with it -- according to researchers at the University of Wisconsin-Madison.

"There has been a lot of work in animals linking both acute and chronic stress to changes in a part of the brain called the prefrontal cortex, which is involved in complex cognitive abilities like holding on to important information for quick recall and use," says Jamie Hanson, a UW-Madison psychology graduate student. "We have now found similar associations in humans, and found that more exposure to stress is related to more issues with certain kinds of cognitive processes."

Children who had experienced more intense and lasting stressful events in their lives posted lower scores on tests of what the researchers refer to as spatial working memory. They had more trouble navigating tests of short-term memory such as finding a token in a series of boxes, according to the study, which will be published in the June 6 issue of the Journal of Neuroscience.

Brain scans revealed that the anterior cingulate, a portion of the prefrontal cortex believed to play key roles in spatial working memory, takes up less space in children with greater exposure to very stressful situations.

"These are subtle differences, but differences related to important cognitive abilities" Hanson says.

But they maybe not irreversible differences.

"We're not trying to argue that stress permanently scars your brain. We don't know if and how it is that stress affects the brain," Hanson says. "We only have a snapshot -- one MRI scan of each subject -- and at this point we don't understand whether this is just a delay in development or a lasting difference. It could be that, because the brains is very plastic, very able to change, that children who have experienced a great deal of stress catch up in these areas."

The researchers determined stress levels through interviews with children ages 9 to 14 and their parents. The research team, which included UW-Madison psychology professors Richard Davidson and Seth Pollak and their labs, collected expansive biographies of stressful events from slight to severe.

"Instead of focusing in on one specific type of stress, we tried to look at a range of stressors," Hanson says. "We wanted to know as much as we could, and then use all this information to later to get an idea of how challenging and chronic and intense each experience was for the child."

Interestingly, there was little correlation between cumulative life stress and age. That is, children who had several more years of life in which to experience stressful episodes were no more likely than their younger peers to have accumulated a length stress resume. Puberty, on the other hand, typically went hand-in-hand with heavier doses of stress.

The researchers, whose work was funded by the National Institutes of Health, also took note of changes in brain tissue known as white matter and gray matter. In the important brain areas that varied in volume with stress, the white and gray matter volumes were lower in tandem.

White matter, Hanson explained, is like the long-distance wiring of the brain. It connects separated parts of the brain so that they can share information. Gray matter "does the math," Hanson says. "It takes care of the processing, using the information that gets shared along the white matter connections."

Gray matter early in development appears to enable flexibility; children can play and excel at many different activities. But as kids age and specialize, gray matter thins. It begins to be "pruned" after puberty, while the amount of white matter grows into adulthood.

"For both gray and white matter, we actually see smaller volumes associated with high stress," Hanson says. "Those kinds of effects across different kinds of tissue, those are the things we would like to study over longer periods of time. Understanding how these areas change can give you a better picture of whether this is just a delay in development or more lasting."

More study could also show the researchers how to help children who have experienced an inordinate amount of stress.

"There are groups around the country doing working memory interventions to try to train or retrain people on this particular cognitive ability and improve performance," Hanson says. "Understanding if and how stress affects these processes could help us know whether there may be similar interventions that could aid children living in stressful conditions, and how this may affect the brain."

Share this story on Facebook, Twitter, and Google:

Other social bookmarking and sharing tools:

Story Source:

The above story is reprinted from materials provided by University of Wisconsin-Madison.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

Journal Reference:

J. L. Hanson, M. K. Chung, B. B. Avants, K. D. Rudolph, E. A. Shirtcliff, J. C. Gee, R. J. Davidson, S. D. Pollak. Structural Variations in Prefrontal Cortex Mediate the Relationship between Early Childhood Stress and Spatial Working Memory. Journal of Neuroscience, 2012; 32 (23): 7917 DOI: 10.1523/JNEUROSCI.0307-12.2012

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

the weeknd payroll tax payroll tax aisha khan alanis morissette vanessa bryant vanessa bryant

Wednesday, June 6, 2012

Do you ask visitors to remove their shoes? in Home and Family Forum

hermine ?#1 [url] [-]

Moderator

Super Member

Posts: 10545

05/06/12 4:26 PM

Moderator

The world is big enough to satisfy everyone`s need, but will always be too small to satisfy everyone`s greed. Mahatma Gandhi

Last Edited By: hermine 05/06/12 4:40 PM. Edited 1 time.

jeb bush sherry arnold snooty fox el debarge portland weather clintonville battlestar galactica blood and chrome

How to fix the Home button on a Verizon or Sprint iPhone 4

If the Home button on your Verizon or Sprint iPhone 4 is not responding when you press it, or sometimes misreads a double tap, you may need to get it fixed. If you're out of warranty and don't want to pay to have someone else do it for you, it's absolutely possible to DIY repair it. This isn't the easiest repair in the world, but if you want to save some cash, and you've got some patience and just a few ninja skills up your sleeve, follow along.

kelsey grammer martin henderson mlk day golden globes 2012 winners golden globes 2012 red carpet golden globes red carpet nfc championship game

Google Maps go off-road and offline

2 hrs.

Rosa Golijan

Many of us rely on Google Maps to find our way around, but the service doesn't help us much once we leave the roads or our Internet connections. That's about to change?? and everything's getting more accurate, too, according to the search giant.

During a press event in San Francisco, Wednesday,?Brian McClendon?? Vice President of Engineering for Google Maps?? discussed how the service will let us go off-road, thanks to something called?Street View Trekker.

Trekker is a way for Google to go into places where the traditional Street View cars can't. All the gear necessary for Google staff to photograph the spots only accessible by foot fits into a backpack. This means that Street View will soon let you explore ski slopes, canyons, and more.?

McClendon also focused on how the company is working to keep?Google Maps up-to-date and?accurate. As the world is constantly changing?? we're constantly constructing something new, after all?? this is a "never?ending job," says McClendon.

Google regularly cross-checks its maps, according to McClendon. This allows the company to ?significantly update its data. Feedback from users who report problems and changes via Google's Map Maker tool helps, too.

That's fine and dandy, but what good are these snazzy maps when you can't access them without a data connection?

Well, that concern will soon?be moot. Google is going to launch offline Google Maps for Android in the next few weeks. This means that you'll be able to use Google Maps even if you are on the subway or in another spot that lacks Internet connectivity. All you have to do is select the regions you need to explore while offline and download them. Google will show you how much space you'll need to save the relevant files.

The Google press conference preempts?Apple's?annual Worldwide Developers Conference (WWDC)?keynote on June 11, when it's expected the iPhone maker will announce its own map application.?According to BGR's Jonathan Geller, iOS 6 ? the next version of Apple's mobile operating system ??will bring 3-D mapping features which use?mapping technology developed by Apple.?

No word on whether Phone users will get to enjoy an?similar feature to the updates Google announced for Android, though that may not be a concern if the reports of Apple ditching Google Maps are true.

Want more tech news, silly puns, or amusing links? You'll get plenty of all three if you keep up with Rosa Golijan, the writer of this post, by following her on?Twitter, subscribing to her?Facebook?posts,?or circling her?on?Google+.

ovechkin one world trade center bks new dark knight rises trailer khloe and lamar oklahoma city thunder act

Tuesday, June 5, 2012

Operating Minimal In Money? Employ this Network marketing business

Paying for traders might be extremely intrusive process. Possible buyers will certainly feel they own the proper to know regarding every part of your enterprise and may get a lot of inquiries to suit your needs. Be sure you are generally geared in what?s going to make one of the most income any kind of time provided second.

Generate an ergonomic desk workplace, compensating particular awareness of the placement of the track or maybe laptop display. Forcing your own neck of the guitar right through the day to enjoy a pc display can be quite uncomfortable and may quite possibly cause permanent neural injuries. In case you will be expending lots of time your desk, purchase the greatest cinema seat that one could have the funds for. This is also true for the key-board, computer mouse mat, computer mouse, lamps, etc. Consider setting a budget for the having; around $200 must be adequate.

Manage your home business, but make sure you take care of a person also. Owning a work-at-home business has the potential to become fulfilling, but in the event you prioritize function over your self, oneself regard can surface area. Remember to exercise, avoid snack excessive and bath every early morning. This can help yourself esteem and also make other people enjoy a person.

Search engine marketing is essential to make your home based business much more obvious on the internet. Search engine optimization, generally labeled as SEO, helps you to increase your rank on the net. This could greatly enhance revenue exponentially with regard to home businesses. It doesn?t matter what achievable to do SEO function on your, especially with the several providers offered.

Tend not to foresee immediate accomplishment due to the fact you might be on the enterprise system you have deemed likely to convey income in the future. Creating a prosperous opportunity will take period. Remain devoted as well as wait for that will large benefit which is within the future.

Any display drive will be a terrific way to less difficult very important business info. If these kinds of datas are generally damaged, you can potentially lose big money and also standard difficult experience compensating your own taxes. You can also employ an internet backup remedy like Mozy.

When many people remain utilizing old-fashioned checks to purchase goods, advance payment these people right after getting these people. In case you?re presently longing in order to sign up your hard earned money at the financial institution, you ought to rather undertake it more frequently. The actual for a longer time you retain the inside your control, the particular likelier it is you will misplace it. Make sure that whenever you perform produce a pay in, ought to thus having a live your life teller rather than a good ATM equipment. This way you should which they money will probably the proper spot without the difficulties.

A top notch approach throughout home business is always to often monitor the purchase price tips your competition utilize. Doing this can make sure most likely even now competitive in the industry when compared with other companies.

You ought to have informed about how you can optimise search results because this will likely support cultivate your own ranking in the effect web pages connected with inquiries that refer in your particular niche. When you are more noticeable throughout search engine results, you will observe a growth inside website visitors aimed at your web. Everybody offers thoughts upon an unsecured loan start this particular, so do your research before you start.

If you are managing an internet business, the particular support of the acquaintances could possibly huge help. Search out other business people along with think of starting off your own group. Although these people may personal profitable business in a various industry, ultilise all of them like a way to obtain enthusiasm that may provide creativity in creating a successful opportunity.

Consider your own clients to be able to meals as well as activity, and you might obtain tax fractures. Once you relieve the clients to a dinner and also go over company, an individual have entitlement to deduct the particular dinner expenses for your taxes. Save your receipts from these actions, as you?ll need to support thees were really prospective or maybe very consumers.

From this article you can see, it will require some function as well as dedication to create the particular bounce. Whenever you manage to pull via along with stick to the routine, it will be easy to be able to accurately symbolize your own fantasy in the company?s photo as well as set up something which is definitely long-lasting along with positive over the years.

Source: furniture shop in Mumbai

As this particular really being mentioned, the actual writer Dr. Henry Ghazalah is famous for his excellent perform inside scientific and editorial writing and is credited for among the finest author on the net.

barista university of kentucky ncaa oakland news alec baldwin alec baldwin college basketball

Home Improvement - Benefits for Hardwood Flooring Installations

Every type of flooring has its pros and cons, and hardwood floors are no exception. The benefits and disadvantages of various floors will depend on the homeowners. However, homeowners that choose hardwood floors will soon realize that these floors have more advantages than disadvantages. One important thing that homeowners should always keep in mind is that moisture is not good for these floors. Heavy moisture can damage the floor even though there are moisture barriers nowadays. These floors take in moisture from all angles; therefore, spilled water, subfloor condensation, wet basements, broken pipes, weather and temperature changes all impinge on the floor.

A number of professionals advise against installing hardwood flooring Atlanta in basements and bathrooms. However, there are experts who will, on the other hand, recommend the use of the right materials and maintenance. They also recommend that a homeowner uses suitable moisture protection and takes preventative measures when dealing with hardwood floors. This allows homeowners to use hardwood in their bathroom and basement without worry. However, these enhancements require additional materials and labor, and can be rather costly.

In order to deal with the natural contraction and expansion of the hardwood flooring, homes with unstable temperature should control humidity levels. The most effective way of controlling humidity is by making use of a humidifier. The floor can gap, crown or even cave in if the homeowner leaves the humidity uncontrolled. Whereas hardwood may be sensitive to moisture, its advantages still surpass those of other types of floors. For instance, hardwood installation increases the value of the home, in addition to adding to the solidity of the structure.

In addition to that, hardwood flooring Atlanta can last for the entire lifetime of the property owner, given the owner properly maintains and cares for it. These floors are not as expensive to maintain as other types of floors. For example, the cost of maintenance for hardwood floors is less than that of carpets. When it comes to hardwood floors, refinishing and sanding can easily take care of dents, scratches and stains. Moreover, hardwood floors offer a warmer feel than vinyl, ceramic or stone floors.

Furthermore, hardwood flooring is quite flexible when it comes to interior design. These floors can match any room or season. The color, grains, finishes and styles of hardwood floors make the home cozy, comfortable, light and airy. These floors can offer a room a rustic appeal, and can make the home elegant and engaging. Hardwood floors match a wide range of interior design plans. The versatility of these floors means that the floor can blend in with trends for d?cor, design and furniture over the years. It is imperative that a homeowner consults a professional before installing hardwood floors in his home.

Flooring Atlanta - Hardwood flooring has quite a number of benefits to the homeowner compared to other floor plans. To learn more about the advantages of these floors, visit Mrhardwoodinc.com.

This article has been viewed 27 time(s).

It is a violation of our terms and conditions for writers to submit material which they did not write and claim it as their own. If this article infringes on your copyrights, you MUST either call us at 706-866-2295 or send proof of infringement along with the offending article's title, URL, and writer name to

IdeaMarketers.com
Attn: Marnie Pehrson - Copyright Concern
514 Old Hickory Ln
Ringgold GA 30736 USA
If you email us or use our problem submission form, we CANNOT guarantee we'll receive your notice!

michael turner split pea soup land of the lost cleveland cavaliers cleveland cavaliers war horse k cups

Investigational diabetes drug may have fewer side effects

Public release date: 4-Jun-2012
[ | E-mail |

Share ]

Contact: Jim Dryden
jdryden@wustl.edu
314-286-0110
Washington University School of Medicine

Drugs for type 2 diabetes can contribute to weight gain, bone fractures and cardiovascular problems, but in mice, an investigational drug appears to improve insulin sensitivity without those troublesome side effects, researchers at Washington University School of Medicine in St. Louis have shown.

The experimental medicine works through a different pathway, which could provide additional molecular targets for treating insulin resistance and diabetes. The new study appears online in the Journal of Biological Chemistry.

"Current diabetes medications activate a receptor that improves insulin sensitivity, but unfortunately also contributes to side effects that make some people discontinue the medication, contributing to other health problems," says principal investigator Brian N. Finck, PhD. "So even though these drugs are effective, we'd really like to find new insulin-sensitizing therapies that would avoid activating the same receptor."

Finck, a research assistant professor of medicine in the Division of Geriatrics and Nutritional Science, worked with colleagues at the University of Michigan and at the drug discovery company Metabolic Solutions Development Co., LLC. The scientists studied one of the company's investigational drugs, MSD-0602, focusing on its effects in obese mice.

The drug improved blood glucose levels and insulin tolerance in the mice, as did the two diabetes drugs that already are on the market: rosiglitazone (Avandia) and pioglitazone (Actos). All three medications appeared to be about equally effective, but MSD-0602 didn't bind to and activate a receptor in cells called PPAR?. Rather, the investigational drug clings to the mitochondria, part of the cell that produces energy.

"The drug altered the cell's ability to generate energy," Finck says. "And it also seems to have an anti-inflammatory role in the cell. We also found that the drug improved insulin sensitivity in many different kinds of cells including muscle, fat and liver cells."

Next, he and his colleagues will attempt to identify proteins that bind to the mitochondrial membrane. Future therapies then could be developed specifically to bind to those proteins while avoiding activation of the PPAR? pathway.

"During the last few years there has been some hesitation in the drug-development business about targeting PPAR? based on what we've learned about side effects from drugs that regulate that pathway," Finck says. "So the biologist in me is very interested in identifying other targets for diabetes drugs and understanding their role in regulating metabolism."

Meanwhile, Metabolic Solutions is testing the investigational drug in patients as part of phase II clinical trials to learn how well it controls their blood glucose.

###

Chen Z, Vigueira PA, Chambers KT, Hall AM, Mitra MS, Qi N, McDonald WG, Colca JR, Kletzien RF, Finck BN. Insulin resistance and metabolic derangements in obese mice are ameliorated by a novel peroxisome proliferator-activated receptor ?-sparing thiazolidinedione. Journal of Biological Chemistry, published online May 2012; http://www.jbc.org/content/early/2012/05/23/jbc.M112.363960.

McDonald, Colca and Kletzein are employed by Metabolic Solutions Development Co., LLC.

Funding comes from the National Institute of Diabetes and Digestive and Kidney Diseases, and the National Institute on Alcohol Abuse and Alcoholism of the National Institutes of Health (NIH), with additional grants from the Barnes-Jewish Hospital Foundation and the American Liver Foundation. NIH grant numbers R41 DK084596, R42 AA021228, P30 DK52574, P30 DK56341, and T32 DK007296.

Washington University School of Medicine's 2,100 employed and volunteer faculty physicians also are the medical staff of Barnes-Jewish and St. Louis Children's hospitals. The School of Medicine is one of the leading medical research, teaching and patient care institutions in the nation, currently ranked sixth in the nation by U.S. News & World Report. Through its affiliations with Barnes-Jewish and St. Louis Children's hospitals, the School of Medicine is linked to BJC HealthCare.

[ | E-mail | Share ]
?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Investigational diabetes drug may have fewer side effects Public release date: 4-Jun-2012
[ | E-mail | Share ]
Contact: Jim Dryden
jdryden@wustl.edu
314-286-0110
Washington University School of Medicine

Drugs for type 2 diabetes can contribute to weight gain, bone fractures and cardiovascular problems, but in mice, an investigational drug appears to improve insulin sensitivity without those troublesome side effects, researchers at Washington University School of Medicine in St. Louis have shown.

The experimental medicine works through a different pathway, which could provide additional molecular targets for treating insulin resistance and diabetes. The new study appears online in the Journal of Biological Chemistry.

"Current diabetes medications activate a receptor that improves insulin sensitivity, but unfortunately also contributes to side effects that make some people discontinue the medication, contributing to other health problems," says principal investigator Brian N. Finck, PhD. "So even though these drugs are effective, we'd really like to find new insulin-sensitizing therapies that would avoid activating the same receptor."

Finck, a research assistant professor of medicine in the Division of Geriatrics and Nutritional Science, worked with colleagues at the University of Michigan and at the drug discovery company Metabolic Solutions Development Co., LLC. The scientists studied one of the company's investigational drugs, MSD-0602, focusing on its effects in obese mice.

The drug improved blood glucose levels and insulin tolerance in the mice, as did the two diabetes drugs that already are on the market: rosiglitazone (Avandia) and pioglitazone (Actos). All three medications appeared to be about equally effective, but MSD-0602 didn't bind to and activate a receptor in cells called PPAR?. Rather, the investigational drug clings to the mitochondria, part of the cell that produces energy.

"The drug altered the cell's ability to generate energy," Finck says. "And it also seems to have an anti-inflammatory role in the cell. We also found that the drug improved insulin sensitivity in many different kinds of cells including muscle, fat and liver cells."

Next, he and his colleagues will attempt to identify proteins that bind to the mitochondrial membrane. Future therapies then could be developed specifically to bind to those proteins while avoiding activation of the PPAR? pathway.

"During the last few years there has been some hesitation in the drug-development business about targeting PPAR? based on what we've learned about side effects from drugs that regulate that pathway," Finck says. "So the biologist in me is very interested in identifying other targets for diabetes drugs and understanding their role in regulating metabolism."

Meanwhile, Metabolic Solutions is testing the investigational drug in patients as part of phase II clinical trials to learn how well it controls their blood glucose.

###

Chen Z, Vigueira PA, Chambers KT, Hall AM, Mitra MS, Qi N, McDonald WG, Colca JR, Kletzien RF, Finck BN. Insulin resistance and metabolic derangements in obese mice are ameliorated by a novel peroxisome proliferator-activated receptor ?-sparing thiazolidinedione. Journal of Biological Chemistry, published online May 2012; http://www.jbc.org/content/early/2012/05/23/jbc.M112.363960.

McDonald, Colca and Kletzein are employed by Metabolic Solutions Development Co., LLC.

Funding comes from the National Institute of Diabetes and Digestive and Kidney Diseases, and the National Institute on Alcohol Abuse and Alcoholism of the National Institutes of Health (NIH), with additional grants from the Barnes-Jewish Hospital Foundation and the American Liver Foundation. NIH grant numbers R41 DK084596, R42 AA021228, P30 DK52574, P30 DK56341, and T32 DK007296.

Washington University School of Medicine's 2,100 employed and volunteer faculty physicians also are the medical staff of Barnes-Jewish and St. Louis Children's hospitals. The School of Medicine is one of the leading medical research, teaching and patient care institutions in the nation, currently ranked sixth in the nation by U.S. News & World Report. Through its affiliations with Barnes-Jewish and St. Louis Children's hospitals, the School of Medicine is linked to BJC HealthCare.

[ | E-mail | Share ]
?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

wiz khalifa taylor allderdice eddie royal brandon marshall iditarod nfl free agents 2012 encyclopedia brittanica nfl free agency

Monday, June 4, 2012

CA primary: Alan Grayson on Lee Rogers, running against Buck "Drones R Us" McKeon (Americablog)

Share With Friends:

| Politics - Top Stories Stories, RSS Feeds and Widgets via Feedzilla.

marine helicopter crash chicago weather star jones wheres my refund photo of whitney houston in casket carrot top george huguely

For Those Who Haven't Initiated Building Your Email List As Of Yet ...

Creating a list is one of the most important things you can do in order to help build a successful business and anyone that has been an Internet marketer for a while already is aware of this. If your completely new, let me tell you right now, you have to start building your own list. There, now you know. Buy email lists. In the Internet marketing field you will hear everyone assuring you how important it is to build your own list. Here we will go over exactly why this is so important and also share a few ways you could start building your own list.

Why Every Single Internet Marketer Must Have Their Very Own List. Buy email lists.

So just why is list building so important to the success of my online business? As an example, let?s assume you promote weight loss cookbooks and you offered one about low fat food preparation to someone. If your customer was required to sign up to your list as part of the purchase process, you can certainly promote other wellness related cookbooks to them. Because this person already bought one product from you, you know they are a buyer and more likely to purchase other products from you in the future so long as they are about the very same subject.

Now let?s say your into arts and crafts and you have an e-book which usually sells arts and crafts projects. Should you have had your own list of people that were definitely into arts and crafts, that you can email every week and market your arts and crafts e-book to, you would certainly make more sales. Buy email lists.

A lot of people don?t understand the importance of a list, every highly effective Internet marketer will tell you that each and every one of your list members are in fact worth $1 a month. So why don?t we say you end up developing a huge list of 5,000 folks who are all interested in one type of niche, your list should be earning you about $5,000 every single month.

OK Lists Are Important But Exactly How Do I Build One. Buy email lists.

Creating your own email list is not that hard, but there are some items you will need to get moving. The very first thing you are going to want is your own website and website name. You will need an auto-responder, this can make it really easy to contact your existing list at once instead of sending out 1 e mail at a time from your email account. And lastly you really should have some type of product that you can give to people to get them to sign up on your list.

Buy email lists. The moment you have these three things you?re ready to go. We will use the arts and crafts as the example but this is the same for any niche or product your advertising and marketing. You have your domain address so now you just have to go on the web and find a free squeeze page creator and build a simple page giving away your free gift. They enter their name and email in to the auto-responder form you have got on that page in order to get this product. As soon as they sign up, they will receive an email which thanks them for subscribing and also explain to them that they will need to verify that they joined up by clicking a link. Once they click the link in the email, they shall be saved in your list and they will furthermore be redirected to the webpage where they can obtain their free product. You have now added a new person to your emailing list that is worth roughly $1 per month.

Buy Email Lists

Tags: success with anthony, success with anthony review, success with anthony reviews, success with anthony scam

This entry was posted on Sunday, June 3rd, 2012 at 6:04 PM and is filed under Scotty's blog. You can follow any responses to this entry through the RSS 2.0 feed. Both comments and pings are currently closed.

christina aguilera tupac hologram pulitzer prize winners nfl 2012 schedule gmail down tim lincecum

Sunday, June 3, 2012

Egypt's Mubarak sentenced to life, protests erupt

CAIRO (Reuters) - Hosni Mubarak, toppled by an uprising last year after 30 years ruling Egypt, was sentenced to life imprisonment on Saturday for his role in killing protesters after a trial that sets a precedent for holding Middle East autocrats to account.

But it was not enough for thousands of Egyptians who poured onto the streets after the verdict. Some wanted Mubarak executed, others feared the judge's ruling exposed weaknesses in the case that could let the former military strongman off on appeal.

Protesters gathered in Cairo's Tahrir Square, focus for the uprising that drove Mubarak, now 84, from office on February 11, 2011. Others in the second city of Alexandria chanted: "We are done with talk, we want an execution!"

The ruling came at a politically fraught time for Egypt, two weeks before a run-off in its first free presidential election that will pit the Muslim Brotherhood, which was banned under Mubarak, against the deposed autocrat's last prime minister.

Mubarak was wheeled into a courtroom cage on a hospital stretcher to join co-defendants including his two sons Alaa and Gamal, former Interior Minister Habib al-Adli and six security officials.

"The court has ordered a punishment for Hosni Mubarak of life in prison based on charges of participating in crimes of killing and attempted killing," Judge Ahmed Refaat told the hushed courtroom.

Propped up on the hospital stretcher and wearing sunglasses, Mubarak heard the verdict stony-faced. He was acquitted on a separate corruption charge.

Refaat sentenced Adli to life in prison but acquitted the senior security officials for lack of evidence.

He quashed charges against Mubarak's sons, relating to abuse of power and graft, but a new case brought against them this week for stock market fraud will keep them behind bars for now.

Businessman and Mubarak ally Hussein Salem, being tried in absentia, was acquitted of corruption charges.

After a silence during sentencing, scuffles broke out inside the court between security officers and people chanting "Void, void" and "The people want the cleansing of the judiciary".

It was the first time an ousted Arab leader had faced an ordinary court in person since a wave of uprisings shook the Arab world last year, sweeping away four entrenched rulers.

Rather than a healing experience that many Egyptians wanted, many saw the trial that acquitted top security officials as showing how much of Mubarak's old order was still in place.

ISLAMISTS CALL FOR PROTESTS

Islamists and others called for protests on Saturday. But some Egyptians said Mubarak's sentencing was enough, even if they were unhappy that security officials were off the hook.

"I think the verdict on Mubarak is fair, he is over 80 years old and a life in prison verdict is a hard one, as it means he will certainly spend all his remaining years in jail," said Ahmed Raouf, 30, who works at a private Cairo computer firm.

The Muslim Brotherhood demanded a re-trial for Mubarak, who made Egypt into a staunch Arab ally of the United States.

"The public prosecutor did not carry out its full duty in gathering adequate evidence to convict the accused for killing protesters," said Yasser Ali, campaign spokesman for Brotherhood presidential candidate Mohamed Mursi.

Mursi has vowed that if he is president, he would use the courts to ensure his predecessor stayed in jail. "It is not possible to release Mubarak," he told Reuters on Thursday. "I promise the martyrs, we will retrieve their rights in full, God willing.

About 850 people were killed in the 18-day revolt that toppled Mubarak.

Ahmed Shafiq, Mubarak's last prime minister, a former air force chief like his old boss and Mursi's opponent in the presidential run-off, calls Mubarak a role model. He said on his Facebook page that the trial showed no one was above the law.

"This verdict brings Egypt back to its leading regional role as the country witnesses the first condemnation of an Arab pharaoh who ruled for 30 years," said Nabil Abdel Fattah from the Al-Ahram Centre for Political and Strategic Studies.

But he said the verdict would be a political football in the election. He said Mursi wanted to show he was the only one who could reform the system and Shafiq would seek to prove that this showed the judiciary could deliver a tough sentence, despite criticism of the ruling by protesters.

Shafiq has vowed to restore order swiftly after 15 months of turmoil that has left many Egyptians exhausted. Any new violence could swing other ordinary Egyptians behind him.

State television said Mubarak, suffered a "health crisis" when he was taken by helicopter from the court to Cairo's Tora prison, where he was admitted to a hospital facility. Mubarak had been held at a luxurious military-run hospital during the 10-month trial.

One medical source said Mubarak had argued with those around him when he had landed at Tora, refusing to leave the aircraft.

Mubarak routinely appeared in court on a stretcher, but it is not clear what ailed him. He had occupied a large hospital suite and was free to see relatives, walk in the garden and exercise, news reports and a hospital source said this week.

Al Jazeera reported that Mubarak would lodge an appeal. His lawyers could not be reached immediately for comment on the report.

Outside the court, Soha Saeed, wife of one of those killed during the anti-Mubarak revolt, shouted: "I'm so happy, I'm so happy." But, as the details of the verdict sunk in, protesters clashed with police, hurling stones and criticizing the court.

Despite Mubarak's life sentence, lawyers acting for the families of victims in the uprising said the acquittal of the six security officials showed the weakness of the prosecution case and suggested the jailed president could win an appeal.

"Regarding accusations against the police leadership, the court is of the opinion that none of the actors who committed the crimes of murder were caught during or after the events, so there is no direct evidence for the charges," the judge said.

Charges against the six included complicity in killing protesters and failing to prevent damage to public property.

New York-based Human Rights Watch said the ruling "sends a powerful message to Egypt's future leaders that they are not above the law".

But it said acquittals of security officials due to insufficient evidence "highlights the failure of the prosecution to fully investigate responsibility for the shooting of protesters", a possible green light for future abuses.

The lawyers for the victims' families said the verdicts against Mubarak and Adli were designed to appease public anger while leaving room for them to be overturned on appeal.

"DEEP DARKNESS"

Refaat opened Saturday's proceedings by hailing Egyptians for removing the only leader many of them had known.

"The people of Egypt woke on Tuesday, January 25, 2011, to a new dawn, hoping that they would be able to breathe fresh air ... after 30 years of deep, deep, deep darkness," he said.

Yet many Egyptians are still waiting for the light - the messy trial and its aftermath typifying the chaos and confusion that have marked a political transition led by the military.

The ruling army council that took over when Mubarak quit has promised to hand over to a freely elected president by July 1.

But many Egyptians are fuming that the pillars of Mubarak's authoritarian rule, including the hated police force, have survived his downfall intact.

Hundreds marched on the supreme court building in central Cairo. A number of them hurled stones that smashed windows, but others shouted "Peacefully" at them, stopping the violence. In Tahrir, some protesters burned Shafiq's campaign posters.

Few Egyptians had expected Mubarak to be put to death, although protesters have often hung his effigy from lamp posts.

Hanafi el-Sayed, whose 27-year-old son was killed early in the uprising, traveled from Alexandria for the trial.

"I want nothing less than the death penalty for Mubarak. Anything less and we will not be silent and the revolution will break out again," he said shortly before the verdict.

(Additional reporting by Yasmine, Saleh, Tom Perry, Patrick Werr and Marwa Awad; Writing by Edmund Blair; Editing by Alistair Lyon and Ralph Gowling)

gone with the wind michael jordan checkers imbibe msg network ray j anthony shadid

Is there any one Who Define me-Secured Loan Vs Unsecured Loans?

Question by : Is there any one Who Define me-Secured Loan Vs Unsecured Loans?

Best answer:

Answer by Adam N
secured is when they ask for collateral like a house or car or something, so if you can?t repay the debt they take the collateral instead. An example of a secured loan is a mortgage.

Unsecured is when they don?t ask for collateral. An example is a credit card.

What do you think? Answer below!

This entry was posted on Saturday, June 2nd, 2012 at 6:23 pm and is filed under loans. You can follow any responses to this entry through the RSS 2.0 feed. You can leave a response, or trackback from your own site.

howard hughes nationwide race wanderlust gone tyler perry good deeds pretty in pink nba all star game

Plane crashes in Nigeria's Lagos with 147 on board

nfl mock draft project m rubio colts colts big ten tournament 2012 dennis quaid

Saturday, June 2, 2012

back belts

Back accidents are classified as the leading explanation for disability during the Us for folks youthful than forty five years of age and have been quite possibly the most costly well-being care dilemma for the 30-50 12 months aged age team [Bureau of Labor Statistics. Dropped function time accidents and illnesses: Traits and resulting time away from perform. U.S. Section of Labor, Washington, D.Do., 1998.].

There is evidence that very low again belts are handy in guarding the worker from small back damage. Even so, theres a pervasive experience that carrying these belts confers complete protection. That may be not the situation. Staff ought to be instructed in good lifting methods. The again belts ought to be part of an in depth course of again care stressing right ergonomics, correcting prospective back again overload situations, and educating personnel on injury avoidance.

At the exact time workers have to be screened for cardiovascular probability. Mounting details suggests these again belts are accountable for considerable will increase in blood pressure and coronary heart rate. Naturally, this poses a hazard for people who currently have other probability things for heart problems.

Lastly, the worker really should be told not to dress in the belt for extended durations of time. This is because the persistent use of these belts at some point prospects to weakening on the bodys natural ?corset? of core muscular tissues.

Additionally, staff ought to be instructed in appropriate core strengthening approaches coupled with standard general health and fitness.

?Back school? education and assessment from the job web page for proper ergonomics is additionally recommended.

Summary recommendations:

o Maintain ideal excess weight

o Exercise frequently

o Maintain proper human body mechanics and core strengthening

o Learn proper lifting approaches and make sure the perform area is ergonomically ?friendly?

o Use back again belts judiciously

o Get your heart and blood pressure checked out.

??????
?????? ??

Sorry, the comment form is closed at this time.

mountain lion taylor momsen xbox live update joan rivers gary carter dies oolong tea survivor one world

$509995 :: 2 Sherwood CT, Lake Oswego OR, 97034 ? Lake ...

Posted by admin on Jun 2, 2012 in Blog

Property Photo

5 beds, 3 full, 1 part baths
Home size: 3,306 sq ft
Lot Size: 10,890 sq ft
Property Type: DETACHD
MLS Number: 12311353
Community: WESTRIDE

Listed with Hasson Company Realtors

Brought to you by Chris Larsson, Coldwell Banker Seal. Call me today at 503-683-2897!

The content relating to real estate for sale on this web site comes in part from the IDX program of the RMLS? of Portland, Oregon. All real estate listings are marked with the RMLS? logo, and detailed information about these properties includes the names of the listing brokers. Listing content is ? 2009 RMLS?, Portland, Oregon.

Lake Oswego Map Seach
Tags: real, Lake Oswego OR, 2 Sherwood CT, Oswego, Homes, Coldwell Banker Seal, Lake Oswego Real Estate Agent

Chris Larsson- Lake Oswego Real Estate Agent

Let me help you find everything you need to know about buying or selling real estate in Lake Oswego, OR! I have been a top-producing Coldwell Banker real estate professional for over 8 years in LO. I am 120% dedicated to providing world-class concierge level service to my clientele.

SEARCH THE LAKE OSWEGO MLS AND REAL ESTATE LISTING HERE...

drew brees tim tebow jets katy perry part of me video photoshop cs6 beta nfl news tebow tebow jets

Best Home Based Business Ideas for Dads : Home Health Care

Today,hublot replica much more and much more individuals are commencing to purpose from home. whether or not for non-public or monetary reasons, many individuals are in a placement to gain a decent income even although getting closer to their family. ladies no extended dominate home-businesses. there are numerous dads who have now can be found to be proud masters of lucrative home business.
Are you a father with an entrepreneurial vision? can you can be found throughout your do it yourself determined to begin your non-public business, be your non-public supervisor and invest much more time collectively with your family? Well, the good information could be the reality which you do not need a tremendous money collectively with a posh business office ?C you can start your non-public lucrative institution ideal from home!
It?s extraordinary the quantity of purpose from home possibilities accessible today. Work-from-home is no extended women?s territory. Some dads purpose from home to ensure which they are able to think about much better option of the children. Some purpose from home for monetary reasons. possibly way, much more dads than actually earlier to are determining on to stay at home. you could be astonished to locate out that many of those stay-at-home dads are earning a terrific offer much greater than conventional business office jobs. With internet major the way, there are numerous different home-business recommendations that dads will enjoy. Bizymoms is genuinely a superb supply of particulars for home-businesses. Browse by means of our web-site and you also are particular to can be found throughout an notion you are almost certainly to go forward with.
If you are internet savvy and possess the expertise and know-how to acquire websites, then creating sites could be for you. that is a specific thing you can perform away from your extremely non-public notebook computer computer and many thanks to online marketing and marketing you will possibly possess the ability to market your institution to potential customers online. for individuals who are not as well a terrific offer of the tech-geek, but know your way near to the house, furniture, pipes and home furniture and fittings, then consider commencing your extremely non-public restore shop. although it may need some travel, commencing a home-based restore institution is right if appreciate repairing things. that is extremely lucrative too. favored restore work consist of clocks, bicycles, cupboards as well as other home appliances. when you complete very a few assignments within your neighborhood,swiss replica tag heuer watches you will possibly be astonished how properly word-of-mouth functions as cost-free advertising!
You may also would rather try your hand at composing or editing for individuals who possess a detail eyesight for spelling and grammar. As an editor or writer you can can be found throughout customers who need help with practically any sort of printed material. These could be superior reviews and even institution letters and memos.
Give home institution a try. Bizymoms is genuinely a website dedicated for home-business recommendations and rules of commencing your extremely non-public institution from home. to determine much more recommendations and articles, browse by means of our website, it will provide you with the enhance you need and help you gain a tad of additional income even although developing particular your loved kinds commitments are met.

Random Posts

Filed under: Uncategorized

stacy keibler stacy keibler all star game oscar red carpet daytona 500 start time ryan zimmerman oscars red carpet

Friday, June 1, 2012

Auto Repair Raleigh NC to the Rescue During Car Emergency

You will definitely have a car emergency after a collision, and auto repair raleigh ncauto repair Raleigh NC</a> can give your car, the repair it needs. If the collision is a light one, you?d be lucky to have few scratches, dents and maybe a broken bumper. However, if the collision is strong, you could sustain an injury from bruises to broken ribs. Your car, however, is a different story. Damage on the car can be severe, and after you mend your injuries take your car for auto repair to restore it to its working condition. Though, like your recovery, car repair could take a while, especially if many parts, including the body needs to be fixed, replaced or repaired. ?As to the expenses for auto repair Raleigh NC, ask the auto shop if this offer different payment terms other than straight full cash payment so that you can utilize other options like credit card or installment basis.

stand your ground law dancing with the stars season 14 david garrard bethenny frankel miguel cabrera michael bay ninja turtles san antonio weather

Around world, Bloomberg soda war hard to swallow

Pearl Ganotisi sips from her 24-ounce of soda drinks as she takes her meal in an American hamburger chain Friday, June 1, 2012 in Manila, Philippines. New York Mayor Michael Bloomberg has proposed a ban on the sale of large sodas and other sugary drinks in restaurants, delis and movie theaters in the hopes of combating obesity. Under his plan, sugary drinks would be limited to 16 fluid ounces _ almost half a liter. Around the world, portion sizes are generally smaller. Perceptions of American overconsumption have been fueled by films such as ?Super Size Me? and the spread of U.S. fast-food chains. (AP Photo/Pat Roque)

LONDON (AP) ? New York Mayor Michael Bloomberg has proposed a ban on the sale of large sodas and other sugary drinks in restaurants, delis and movie theaters in the hopes of combating obesity. Under his plan, sugary drinks would be limited to 16 fluid ounces ? almost half a liter.

Around the world, portion sizes are generally smaller. Perceptions of American overconsumption have been fueled by films such as "Super Size Me" and the spread of U.S. fast-food chains.

So while many global citizens reacted with a mix of incredulity, awe and disgust when confronted with some of the sizes of sugary drinks sold stateside, others were less surprised.

"I know what American culture is like ? big portions, not necessarily health-conscious," Gordon Howard, who works in finance, said at a London wine tasting. "They supersize everything."

Like Howard, many people around the world say the notion of a 44-ounce cola doesn't hold much water for them ? but neither did a ban.

LONDON

The idea of drinking that much soda ? or liquid of any kind ? is "excessive" to 32-year-old Simon Robinson, but he said wouldn't care about Bloomberg's ban because he would never drink that much in the first place ? even during a three-hour film.

"I would probably have to go to the bathroom and end up missing half the movie," Robinson said. "It's the people that either want that drink or think it's their right that are going to kick up a fuss."

PARIS

Cafe owner Mourad Rahmani, 30, said he can't imagine such a debate in France. "The biggest size drink we have here is 0.5 liter," Rahmani said, raising an empty pint glass he'd been washing. While he would never think of ordering such a 44 ounce drink himself, Rahmani said he's against the ban. "It's a question of freedom. What's next? Ban hamburgers?"

KAMPALA, Uganda

"A person should have the right to decide what they want to eat and how much," said social worker Frederick Agaba. "This should not be the job of a mayor. In any case, this law would not make a big difference, as elsewhere someone could still take whatever amount of Coke he wants."

MANILA

At Jolibee, a ubiquitous Filipino fast-food chain that's more popular than McDonald's, call center manager Joy Jimenez agreed with Bloomberg's move.

"Kids these days when they see that soft drinks are available, they will just drink and drink," she said. "It is part of government's responsibility to ensure the health of its citizens."

JERUSALEM

In Israel, Yair Foldes said that the New York measure might help address obesity.

"Here I don't think we have that problem but there it might help raise awareness," he said while waiting for a train.

JOHANNESBURG

Shazia Suffla suggested that governments should instead provide more information about how to avoid diseases like diabetes and high blood pressure, and encourage restaurants to offer more healthy choices.

"I'm actually adapting to trying to eat healthily," she said while hearing to a diner near her office to get a grilled chicken sandwich. "But people don't like to be told what to do."

SAO PAOLO

"It's so weird for us, the idea that a person would drink more than a liter of soda ? that's huge! Of course there should be a law to stop that," said Arthur Trigo, a 19-year-old student standing outside a juice stand in a shopping center. "Americans are such exaggerated consumers, they really need to consume less."

___

Associated Press writers Donna Bryson in Johannesburg; Oliver Teves in Manila; Greg Keller in Paris; Tia Goldenberg in Jerusalem; Rodney Muhumuza in Kampala, Uganda; and Bradley Brooks in Sao Paulo contributed to this report.

Associated Press

bonnie raitt internal revenue service intc ipad mini nfl schedule 2012 andrew shaw christina aguilera